Author

Shreya Ghimire

University of IowaORCID 0000-0001-8975-7998Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Alejandro A. PezzuloiD· 3 shared Andrew L. ThurmaniD· 3 shared Biyun Xue· 2 shared Christine Wohlford-Lenane· 2 shared David Kyle MeyerholziD· 2 shared Paul B. McCrayiD· 2 shared Stanley M. PerlmaniD· 2 shared Abhishek VermaiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

Alejandro A. PezzuloORCID

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3 papers

Recent·Most cited

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

Shreya Ghimire, Biyun Xue, Kun Li, Ryan M. Gannon, Christine Wohlford-Lenane, Andrew L. Thurman, Huiyu Gong, Grace C. Necker, Jian Hua Zheng, David Kyle Meyerholz, Stanley M. Perlman, Paul B. McCray, Alejandro A. Pezzulo

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

EBioMedicine · Sep 17, 2025Peer-reviewedCell Biology

A predominately pulmonary activation of complement in a mouse model of severe COVID-19

Peter J. Szachowicz, Christine Wohlford-Lenane, Cobey J. H. Donelson, Shreya Ghimire, Andrew L. Thurman, Biyun Xue, Timothy J. Boly, Abhishek Verma, Leila MašinoviĆ, Jennifer Bermick, Tayyab Rehman, Stanley M. Perlman, David Kyle Meyerholz, Alejandro A. Pezzulo, Yuzhou Zhang, , Paul B. McCray

This study identifies pulmonary complement activation in a mouse model of severe COVID-19, showing local complement production and its role in lung injury.

iScience · Feb 1, 2025Peer-reviewedImmunology

Performance of a scalable extraction-free RNA-seq method

Shreya Ghimire, Carley G. Stewart, Andrew L. Thurman, Alejandro A. Pezzulo

This study evaluates a bulk RNA-seq method using direct cell lysis without RNA extraction, showing it produces high-quality data comparable to traditional methods with lower costs.

bioRxiv · Jan 22, 2021 · PreprintGenomics