Author

Bo Yuan

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Neuroscience· 1 Physiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Gökhan S. HotamışlıgiliD· 2 shared Karen InouyeiD· 2 shared Sheng Tony HuiiD· 2 shared Cody L SlateriD· 1 shared Craig KelleyiD· 1 shared Gizel Askin· 1 shared Grace Y. LeeiD· 1 shared Isabel GrauperaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPhysiology

Gökhan S. HotamışlıgilORCID

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3 papers

Recent·Most cited

Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks

Craig Kelley, Timothy Lantin, Cody L Slater, Marc Sorrentino, Kunpeng Yu, Bo Yuan, Michael Kann, Yuxiang Andy Liu, Jung Soo Kim, Qi Wang

The paper examines how behavioral states influence norepinephrine dynamics in somatosensory and prefrontal cortices during tactile detection tasks, linking pupil size and NE signaling to task performance.

bioRxiv · May 10, 2026 · PreprintNeuroscience

Cholesterol-Responsive Interaction of NFE2L1-INSIG1 Controls VLDL Secretion and MASH Pathogenesis

Shijun Deng, Jessica Freed, Grace Y. Lee, Gizel Askin, Zhe Cao, Özgür Cakici, Bo Yuan, Sheng Tony Hui, Karen Inouye, Isabel Graupera, Gökhan S. Hotamışlıgil

This study identifies a cholesterol-responsive interaction between NFE2L1 and INSIG1 that sustains cholesterol balance and prevents MASH by promoting VLDL secretion.

bioRxiv · Jun 9, 2025 · PreprintPhysiology

An Organism-Level Quantitative Flux Model of Energy Metabolism in Mice

Bo Yuan, Will G. Doxsey, Özlem Tok, Young‐Yon Kwon, Yanshan Liang, Karen Inouye, Gökhan S. Hotamışlıgil, Sheng Tony Hui

The paper develops an organism-level quantitative flux model of energy metabolism in mice by integrating isotope tracing and mass spectrometry, revealing distinct metabolic cycling and oxidation flux patterns for circulating nutrients.

Cell Metabolism · Apr 1, 2025Peer-reviewedSystems Biology