Author

Boris Landa

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:batch correction / integration· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jay S. StanleyiD· 2 shared Yuval KlugeriD· 2 shared Andrew H. Moberly· 1 shared Dmitry KobakiD· 1 shared Esen SefikiD· 1 shared Francesco StrinoiD· 1 shared Hadas BenistyiD· 1 shared Ian D. OdelliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Jay S. StanleyORCID

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3 papers

Recent·Most cited

Principled PCA separates signal from noise in omics count data

Jay S. Stanley, Junchen Yang, Ruiqi Li, Ofir Lindenbaum, Dmitry Kobak, Boris Landa, Yuval Kluger

BiPCA improves PCA for omics count data by adaptively rescaling noise, enhancing biological interpretation and reducing batch effects across multiple modalities.

bioRxiv · Feb 3, 2025 · PreprintBioinformatics

Gene Trajectory Inference for Single-cell Data by Optimal Transport Metrics

Rihao Qu, Xiuyuan Cheng, Esen Sefik, Jay S. Stanley, Boris Landa, Francesco Strino, Sarah Platt, James Garritano, Ian D. Odell, Ronald R. Coifman, Richard Anthony Flavell, Peggy S. Myung, Yuval Kluger

GeneTrajectory infers gene trajectories instead of cell trajectories to uncover progressive gene dynamics in biological processes.

Nature Biotechnology · Apr 5, 2024Peer-reviewedBioinformatics

Dual color mesoscopic imaging reveals spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.

Sweyta Lohani, Andrew H. Moberly, Hadas Benisty, Boris Landa, Miao Jing, Yulong Li, Michael J. Higley, Jessica A. Cardin

The paper uses dual-color mesoscopic imaging in awake mice to show that cholinergic and cortical activity are spatiotemporally heterogeneous and linked to behavioral states.

Nature Neuroscience · Nov 28, 2022Peer-reviewedNeuroscience