Author

Brenda McMahon

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 3 Research Focus:metabolism & bioenergetics· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Amber M. VandevenderiD· 2 shared Bellina A.S. MushalaiD· 2 shared Brett A. KaufmaniD· 2 shared Iain ScottiD· 2 shared Janet R. ManningiD· 2 shared Maryam Sharifi‐Sanjani· 2 shared Michael J. JurczakiD· 2 shared Michael Wayne StoneriD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Amber M. VandevenderORCID

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Author profile →

3 papers

Recent·Most cited

Therapeutic potential of Relaxin-2 in Heart Failure with preserved Ejection Fraction (HFpEF)

Joshua B. Palma, Beth A. Gabris-Weber, Brenda McMahon, Anthony J. Mauro, Cynthia St. Hilaire, Rolando A. Cuevas, Thomas Bernd Dschietzig, Guillermo Romero, Guy Salama

This study investigates the therapeutic effects of synthetic Relaxin-2 in HFpEF, showing it reverses diastolic dysfunction and reduces arrhythmia vulnerability in ZSF1 rats.

bioRxiv · May 18, 2026 · PreprintPhysiology

Adropin protects against cardiac remodeling and metabolic dysfunction in a mouse model of HFpEF

Bellina A.S. Mushala, Michael Wayne Stoner, Maryam Sharifi‐Sanjani, Janet R. Manning, Paramesha Bugga, Nisha Bhattarai, Brenda McMahon, Amber M. Vandevender, Steven J. Mullett, Brett A. Kaufman, Sruti S. Shiva, Cheng Zhang, Eric S. Goetzman, Stephen Y. Chan, Stacy L. Gelhaus, , Iain Scott

This study shows Adropin treatment reverses cardiac dysfunction and metabolic defects in a mouse model of HFpEF by reducing O-GlcNAcylation of LCAD and improving fatty acid oxidation.

bioRxiv · May 3, 2025 · PreprintPhysiology

TCA Cycle Dysfunction and Amino Acid Catabolism Drive Hepatic Steatosis in Mice with HFpEF

Bellina A.S. Mushala, Michael Wayne Stoner, Janet R. Manning, Paramesha Bugga, Nisha Bhattarai, Maryam Sharifi‐Sanjani, Brenda McMahon, Amber M. Vandevender, Steven J. Mullett, Brett A. Kaufman, Sruti S. Shiva, Stacy L. Gelhaus, Michael J. Jurczak, Iain Scott

This study shows that TCA cycle dysfunction and amino acid catabolism in mice with HFpEF drive hepatic steatosis similar to human NAFLD.

bioRxiv · Jun 3, 2024 · PreprintPhysiology