Author

Gayanie Ratnayake

Royal Women's HospitalORCID 0000-0001-6002-4619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander DobroviciD· 2 shared Australian Ovarian Cancer Study· 2 shared Cassandra J. VandenbergiD· 2 shared Elizabeth L. KyraniD· 2 shared Franziska GeissleriD· 2 shared Ksenija NesiciD· 2 shared Lijun XuiD· 2 shared Nadia TraficanteiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alexander DobrovicORCID

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2 papers

Recent·Most cited

Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing

Ksenija Nesic, Franziska Geissler, Lijun Xu, Elizabeth L. Kyran, Sally Beard, Cassandra J. Vandenberg, Brett Liddell, Sam W.Z. Olechnowicz, Monique D. Topp, Orla McNally, Gayanie Ratnayake, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, David D.L. Bowtell, , Matthew J. Wakefield

This study shows that DNMT1 inhibitors reduce BRCA1 promoter methylation in HGSOC, leading to BRCA1 re-expression and PARP inhibitor resistance.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Qi Cai, Tanya Todorova Kwan, Elizabeth Lieschke, Gwo‐Yaw Ho, Holly E. Barker, Justin Bedő, Silvia Casadei, Andrew Farrell, Marc R. Radke, Kristy Shield‐Artin, , Lyndal S. Edwards

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Molecular Cancer · Aug 5, 2024Peer-reviewedGenetic & Genomic Medicine