Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome
Hanjing Peng, Zufeng Guo, Wei Li Wang, Deyao Yin, Shitao Zou, Thomas Asbell, Brett R. Ullman, Maya Thakar, Feiran Zhang, Sam Y. Hong, A. V. Subba Rao, Kunyu Wang, Shuwen Zhang, Zhaolong Wu, Xuemei Li, , Jun O. Liu
This paper identifies rapaprotin as a 26S proteasome assembly inhibitor that is activated by PREP to induce apoptosis and synergizes with proteasome inhibitors in cancer cells.
bioRxiv · Feb 21, 2025 · PreprintPharmacology & Toxicology