Author

Thomas Asbell

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. V. Subba Rao· 2 shared Jun O. LiuiD· 2 shared Brett R. Ullman· 1 shared Christian Burris GockeiD· 1 shared Deyao YiniD· 1 shared Feiran ZhangiD· 1 shared Hanjing Peng· 1 shared Jennifer A. RothiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. V. Subba Rao

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2 papers

Recent·Most cited

Overcoming rapaprotin resistance through inhibition of P-glycoprotein

Qian Zhang, Thomas Asbell, A. V. Subba Rao, Kalyan Kumar Pasunooti, Jian Zhang, Matthew G. Rees, Jennifer A. Roth, Jun O. Liu

This study identifies P-glycoprotein as a mediator of Rapaprotin resistance and shows that co-treatment with tariquidar restores its efficacy in colorectal cancer cells.

bioRxiv · Sep 28, 2025 · PreprintPharmacology & Toxicology

Rapaprotin is Activated by an Endopeptidase to Disassemble 26S Proteasome

Hanjing Peng, Zufeng Guo, Wei Li Wang, Deyao Yin, Shitao Zou, Thomas Asbell, Brett R. Ullman, Maya Thakar, Feiran Zhang, Sam Y. Hong, A. V. Subba Rao, Kunyu Wang, Shuwen Zhang, Zhaolong Wu, Xuemei Li, , Jun O. Liu

This paper identifies rapaprotin as a 26S proteasome assembly inhibitor that is activated by PREP to induce apoptosis and synergizes with proteasome inhibitors in cancer cells.

bioRxiv · Feb 21, 2025 · PreprintPharmacology & Toxicology