Fengyun Sun

A single cell atlas of the mouse seminal vesicle

This study creates a single-cell RNA-seq atlas of the mouse seminal vesicle, identifying secretory and immune cell populations and their transcriptomes.

Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse

The paper shows that Cre recombinase can be transported from somatic tissues to the male reproductive tract in mice, suggesting inter-tissue RNA or protein trafficking.

Deficient spermiogenesis in mice lacking Rlim

This study shows that Rlim is essential for spermiogenesis in male mice, as its deletion leads to defective sperm production and fertility issues.

Cytosine methylation dynamics during post-testicular sperm maturation in mammals

The paper examines cytosine methylation changes in sperm during post-testicular maturation and finds minimal changes, with an unexpected extracellular DNA contamination in caput epididymal sperm.

Small RNAs gained during epididymal transit of sperm are essential for embryonic development in mice

This study shows that small RNAs acquired by sperm in the epididymis are critical for embryonic development in mice, as their absence leads to developmental failure and can be rescued by adding these RNAs.

Small RNAs are trafficked from the epididymis to developing mammalian sperm

The paper shows that small RNAs in mature mammalian sperm originate from epididymal somatic cells, not testicular germ cells, and are delivered via vesicular transport during post-testicular maturation.