Seema S. Lakdawala

A lethal human H5N5 influenza virus isolate exhibits low pandemic risk traits

This study analyzes an H5N5 influenza virus isolate that caused a human fatality, finding it lacks key traits associated with human pandemic potential.

Disruption of a CCR5-like immunoglobulin gene is linked to plague susceptibility in black-footed ferrets

The paper identifies a disrupted CCR5-like immunoglobulin gene in black-footed ferrets linked to increased susceptibility to plague caused by Yersinia pestis.

Variable transmission efficiency of mammalian origin HPAI D1.1 H5N1 strains in ferrets

The paper assesses transmission efficiency of D1.1 H5N1 strains in ferrets, finding only one human isolate efficiently transmits, linked to the PB2 D701N mutation.

Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk

The study assesses the pandemic risk of a fatal zoonotic H3N8 influenza virus from chickens, finding it has moderate pandemic potential due to its ability to infect humans and replicate in human cells.

Development and Characterization of Chicken Lung Organoids for Future In Vitro Modeling of Avian Influenza Virus-Host Cell Interaction

The paper develops chicken lung organoids to model avian influenza virus-host interactions and finds they contain diverse cell types and express relevant viral infection genes.

Within-host adaptive evolution is limited by genetic drift in experimental human influenza A virus infections

This study examines within-host evolutionary dynamics of influenza A virus in humans and ferrets, finding that genetic drift limits selection efficiency in humans but not in ferrets.

Innate antiviral readiness drives the expansion of protective T stem cell memory against influenza

This study identifies innate antiviral readiness as a key driver of TSCM cell expansion, showing its predictive value for viral clearance and vaccine design.

Surveillance on California dairy farms reveals multiple possible sources of H5N1 transmission

The paper investigates H5N1 transmission on dairy farms by sampling air, wastewater, and milk, finding infectious virus in air and wastewater, viral RNA in cow breath, and subclinical infections in cows.

Pre-existing H1N1 immunity reduces severe disease with bovine H5N1 influenza virus

This study shows that pre-existing H1N1 immunity protects ferrets from severe disease caused by bovine H5N1 influenza virus.

Learning the sequence of influenza A genome assembly during viral replication using point process models and fluorescence in situ hybridization

The paper uses fluorescence in situ hybridization and point process models to infer the sequence of vRNP associations during influenza A virus assembly.