Author

Brook T. Wassie

Massachusetts Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ernest FraenkeliD· 2 shared Miriam Adam· 2 shared Aaron P. Frank· 1 shared Ajay PillaiiD· 1 shared Albert Lee· 1 shared Alex Lenail· 1 shared Alexandra B. London· 1 shared Alyssa N. CoyneiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersSystems Biology

Ernest FraenkelORCID

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2 papers

Recent·Most cited

A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses

Sean M. Gross, Mark A. Dane, Rebecca Lee Smith, Kaylyn L. Devlin, Ian C. McLean, Daniel S. Derrick, Caitlin E. Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, John Erol Evangelista, Daniel J. B. Clarke, Zhuorui Xie, Cemal Erdem, Nicholas Lyons, , Laura M. Heiser

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.

Communications Biology · Oct 7, 2022Peer-reviewedSystems Biology

An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Loren Ornelas, Emilda Gomez, Lindsay Panther, Aaron P. Frank, Susan Lei, Berhan Mandefro, Maria G. Bañuelos, Brandon Shelley, Julia Kaye, Leandro de Araújo Lima, Stacia K. Wyman, Ryan G. Lim, Jie Wu, Jennifer T. Stocksdale, Malcolm Casale, , Leslie Michels Thompson

The paper performs an integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients to identify dysregulated pathways and validate them in vivo and in postmortem data.

bioRxiv · Nov 1, 2020 · PreprintNeuroscience