Metabolic imprinting drives epithelial memory during mucosal fungal infection
Jinendiran Sekar, Norma V. Solis, Jian Miao, Nicolas Millet, Bryce Tom, Derek Quintanilla, Aize Pellón, David L. Moyes, Joseph A. Gogos, Harry B. Rossiter, Scott G. Filler, Mihai Gheorghe Netea, Jennifer K. Yee, Marc Swidergall
This study identifies a metabolic-epigenetic mechanism in oral epithelial cells that enhances protection against fungal infection through proline catabolism and mitochondrial function.
bioRxiv · Jul 11, 2025 · PreprintImmunology