Author

C. B. Little

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Li· 2 shared A. Ali· 1 shared A. J. Fosang· 1 shared A. M. Obeidat· 1 shared A.-M. Malfait· 1 shared B. Hu· 1 shared C. Angelucci· 1 shared C. Scanzello· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPathology

J. Li

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Author profile →

4 papers

Recent·Most cited

Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis

A. M. Obeidat, S. Y. Kim, K. G. Burt, B. Hu, J. Li, S. Ishihara, R. Xiao, R. E. Miller, C. B. Little, A.-M. Malfait, C. Scanzello

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

bioRxiv · Oct 14, 2023 · PreprintPathology

Loss of Grem1-articular cartilage progenitor cells causes osteoarthritis.

J. Q. Ng, T. H. Jafarov, C. B. Little, T. Wang, A. Ali, Y. Ma, G. Radford, L. Vrbanac, M. Ichinose, S. Whittle, D. Hunter, T. Lannagan, N. Suzuki, J. M. Goyne, H. Kobayashi, , S. Mukherjee

This study identifies Grem1-articular cartilage progenitor cells as critical for maintaining joint health, and their loss leads to osteoarthritis, with potential therapeutic targeting of FGFR3.

bioRxiv · Mar 29, 2023 · PreprintCell Biology

Understanding the effects of mesenchymal stromal cell therapy for treating osteoarthritis using an in vitro co-culture model

V. Shang, J. Li, C. B. Little, J. J. Li

This study investigates why mesenchymal stromal cell (MSC) therapy for osteoarthritis (OA) has short-term benefits but lacks long-term efficacy using an in vitro co-culture model.

bioRxiv · Aug 25, 2022 · PreprintCell Biology

Cartilage microRNA dysregulation in mouse osteoarthritis overlaps with patient disease candidates

L. H. W. Kung, V. Ravi, L. Rowley, C. Angelucci, A. J. Fosang, K. M. Bell, C. B. Little, J. Bateman

The paper identifies microRNA dysregulation in a mouse osteoarthritis model and finds overlaps with human OA candidates, suggesting potential biomarkers and therapeutic targets.

bioRxiv · Mar 22, 2017Cell Biology