Author

C. Baldock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:cryo-EM· 1

Frequent Co-Authors

A. R. Godwin· 2 shared G. Sengle· 2 shared T. A. Jowitt· 2 shared A. Gerken· 1 shared A. J. Day· 1 shared A. M. Roseman· 1 shared A. Niehoff· 1 shared A. W. W. Langford-Smith· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. R. Godwin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating Wnt signaling

D. Hubmacher, N. Taye, C. Baldock, M. Singh

This study identifies ADAMTSL2 as a regulator of myogenesis by enhancing Wnt signaling, showing its role in promoting myoblast differentiation and muscle development.

bioRxiv · Dec 6, 2022Cell Biology

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory TGFβ-binding site

A. R. Godwin, J. Thomson, D. F. Holmes, C. S. Adamo, G. Sengle, M. J. Sherratt, A. M. Roseman, C. Baldock

The paper reveals the cryo-EM structure of fibrillin microfibrils and shows how mutations disrupt TGFβ signaling by blocking LTBP-1 interaction through long-range structural effects.

bioRxiv · Aug 26, 2022 · PreprintBiochemistry

Transglutaminase mediated asprosin oligomerization allows its tissue storage as fibers

Y. A. Morcos, G. Pryymachuk, S. Luetke, A. Gerken, A. R. Godwin, T. A. Jowitt, N. Piekarek, T. Hoffmann, A. Niehoff, M. Odenthal, U. Drebber, O. Grisk, Y. Ladilov, W. Bloch, B. Callewaert, , G. Sengle

The paper identifies transglutaminase-mediated asprosin oligomerization and extracellular fiber formation in connective tissues, suggesting a new mechanism for tissue storage and regulation of asprosin bioavailability.

bioRxiv · Jan 4, 2022 · PreprintBiochemistry

How the dual PDZ domain from Postsynaptic density protein 95 clusters ion channels and receptors.

N. A. Rodzli, M. P. Lockhart-Cairns, C. Levy, J. Chipperfield, L. Bird, C. Baldock, S. M. Prince

This study reports crystal structures and thermodynamic analysis of the dual PDZ domain of PSD-95, revealing its scaffolding function in clustering ion channels and receptors.

bioRxiv · Sep 19, 2019 · PreprintBiophysics

Heavy chain-1 of inter-α-inhibitor has an integrin-like structure with immune regulatory activities

D. J. Briggs, A. W. W. Langford-Smith, T. A. Jowitt, C. M. Kielty, J. J. Enghild, C. Baldock, C. M. Milner, A. J. Day

This paper identifies HC1 of inter-α-inhibitor as having an integrin-like structure with immune regulatory functions through inhibition of the alternative pathway C3 convertase.

bioRxiv · Jul 8, 2019 · PreprintBiochemistry