Author

D. F. Holmes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Swift· 3 shared M. J. Sherratt· 3 shared B. Derby· 2 shared C. R. Saville· 2 shared E. Emmerson· 2 shared M. J. Hardman· 2 shared V. Mallikarjun· 2 shared A. Adamson· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

J. Swift

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory TGFβ-binding site

A. R. Godwin, J. Thomson, D. F. Holmes, C. S. Adamo, G. Sengle, M. J. Sherratt, A. M. Roseman, C. Baldock

The paper reveals the cryo-EM structure of fibrillin microfibrils and shows how mutations disrupt TGFβ signaling by blocking LTBP-1 interaction through long-range structural effects.

bioRxiv · Aug 26, 2022 · PreprintBiochemistry

Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI.

U. Hansen, D. F. Holmes, P. Bruchner, P. Bishop

bioRxiv · Jun 2, 2020Biochemistry

Estrogen mediates acute elastic fibre homeostasis in skin

C. R. Saville, D. F. Holmes, J. Swift, B. Derby, E. Emmerson, M. J. Hardman, M. J. Sherratt

This study shows that estrogen deficiency reduces skin elasticity and elastic fibre abundance, which can be reversed by estrogen replacement.

bioRxiv · Aug 8, 2019 · PreprintBiophysics

Circadian control of the secretory pathway is a central mechanism in tissue homeostasis

J. Chang, R. Garva, A. Pickard, C.-Y. C. Yeung, V. Mallikarjun, J. Swift, D. F. Holmes, B. Calverley, Y. Lu, A. Adamson, H. Raymond-Hayling, O. Jensen, T. Shearer, Q. J. Meng, K. E. Kadler

The paper identifies a circadian mechanism regulating collagen synthesis, assembly, and degradation to maintain tissue homeostasis in mice.

bioRxiv · Apr 7, 2019Cell Biology

Distinct matrix composition and mechanics in aged and estrogen-deficient mouse skin

C. R. Saville, V. Mallikarjun, D. F. Holmes, E. Emmerson, B. Derby, J. Swift, M. J. Sherratt, M. J. Hardman

This study examines how aging and estrogen deficiency affect skin matrix composition and mechanics in mice, finding contrasting effects on tensile strength and collagen levels.

bioRxiv · Mar 8, 2019 · PreprintBiophysics