A. Summerfield

Peste des Petits Ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue

This study compares immune responses in goats infected with high and low virulent PPRV strains, finding strain-specific differences in early inflammation and lymphocyte suppression.

Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

This study shows that serial passaging of JEV in pigs leads to fitness adaptations and amino acid changes, but not increased direct transmission.

Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids

This study shows MPXV spreads cell-to-cell in human neural organoids, causing neuronal death and neuritic bead formation, and identifies tecovirimat as effective in reducing viral load.

Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node

The paper uses single-cell transcriptomics to analyze dendritic and monocytic cells in bovine mesenteric lymph nodes, identifying distinct clusters and functional properties.

The baseline immunological and hygienic status of pigs impact disease severity of African swine fever

This study shows that the immunological and hygienic status of pigs affects the severity of African swine fever, with SPF pigs showing different immune responses compared to farm-raised pigs.

Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models

The paper compares the fitness of SARS-CoV-2 variants B.1.1.7 and B.1.351 in animal models, finding B.1.1.7 has a fitness advantage in ferrets and mice but not in hamsters.

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

No evidence for human monocyte-derived macrophage infection and antibody-mediated enhancement of SARS-CoV-2 infection

This study shows SARS-CoV-2 and SARS-CoV-1 do not infect human macrophages or induce inflammation, and patient serum does not enhance infection or trigger immune responses in these cells.

Transcriptomic signature and metabolic programming of bovine classical and nonclassical monocytes indicate distinct functional specializations

The paper identifies distinct transcriptomic and metabolic profiles of bovine classical and nonclassical monocytes, revealing their specialized functions in inflammation, tissue repair, and antiviral responses.