C. C. Maley

Epigenome and early selection determine the tumour-immune evolutionary trajectory of colorectal cancer

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.

Testing Adaptive Therapy Protocols using Gemcitabine and Capecitabine on a Mouse Model of Endocrine-Resistant Breast Cancer

This study tests adaptive therapy protocols using gemcitabine and capecitabine on a mouse model of endocrine-resistant breast cancer, finding improved survival with adaptive strategies over high-dose combination therapy.

Germline mutation rate predicts cancer mortality across 37 vertebrate species

The paper finds a positive correlation between germline mutation rates and cancer mortality across 37 vertebrate species.

The relationship between diet, plasma glucose, and cancer prevalence across vertebrates

The paper investigates how diet and plasma glucose levels relate to cancer prevalence across vertebrates, finding negative correlations and trophic level associations.

Life history and cancer in birds: clutch size predicts cancer

This study investigates the relationship between life history traits and cancer prevalence in managed birds, finding that clutch size is positively correlated with cancer and neoplasia prevalence.

The ecology of cancer prevalence across species: Cancer prevalence is highest in desert species and high trophic levels

The paper examines cancer prevalence across 244 vertebrate species, finding higher rates in high trophic levels and low productivity habitats, though only trophic level correlations remained significant after corrections.

Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens.

This study identifies DNA repair gene upregulation and cell extrusion as mechanisms enabling Trichoplax adhaerens to resist high radiation levels.

Elephant Genomes Elucidate Disease Defenses and Other Traits

This study identifies regulatory elements and genes associated with disease resistance and unique traits in Asian and African elephants, highlighting genetic differences in immunity and cancer resistance.

The Evolution of Human Cancer Gene Duplications across Mammals

This study examines cancer gene copy numbers across 63 mammalian genomes, finding a positive correlation between cancer gene copy number and longevity in long-lived species.

Minimal Barriers to Invasion During Human Colorectal Tumor Growth

The paper examines intra-tumoral heterogeneity in colorectal tumors and finds that early multiclonal invasion occurs with minimal barriers to invasion.

Exploiting evolutionary herding to control drug resistance in cancer

This paper demonstrates evolutionary herding in non-small cell lung cancer to control drug resistance by shifting clonal composition and inducing collateral sensitivity.