Author

I. C. Sorribes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Hall· 2 shared C. C. Maley· 2 shared D. Mallo· 2 shared D. Shibata· 2 shared L. M. King· 2 shared M. D. Ryser· 2 shared A. Basu· 1 shared B. Manley· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. Hall

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Author profile →

4 papers

Recent·Most cited

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development

M. D. Ryser, M. A. Greenwald, I. C. Sorribes, L. M. King, A. Hall, J. Geradts, D. L. Weaver, D. Mallo, S. Holloway, D. Monyak, G. Gumbert, S. Vaez-Ghaemi, E. Wu, K. A. Murgas, L. J. Grimm, , S. Hwang

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.

bioRxiv · Oct 1, 2023 · PreprintCancer Biology

Minimal Barriers to Invasion During Human Colorectal Tumor Growth

M. D. Ryser, D. Mallo, A. Hall, T. Hardman, L. M. King, I. C. Sorribes, C. C. Maley, J. R. Marks, E. S. Hwang, D. Shibata

The paper examines intra-tumoral heterogeneity in colorectal tumors and finds that early multiclonal invasion occurs with minimal barriers to invasion.

bioRxiv · Nov 14, 2019Cancer Biology

Mitigating Temozolomide Resistance in Glioblastoma via DNA Damage-Repair Inhibition

I. C. Sorribes, S. K. Handelman, H. V. Jain

This study develops a mechanistic model to identify optimal combination therapies for overcoming temozolomide resistance in glioblastoma by targeting DNA repair enzymes.

bioRxiv · Oct 5, 2019Cancer Biology

Harnessing patient-specific response dynamics to optimize evolutionary therapies for metastatic clear cell renal cell carcinoma - Learning to adapt

I. C. Sorribes, A. Basu, R. Brady, P. M. Enriquez-Navas, X. Feng, J. N. Kather, N. Nerlakanti, R. Stephens, M. Strobl, I. Tavassoly, N. Vitos, D. Lemanne, B. Manley, C. O'Farrelly, H. Enderling

This paper develops a dynamic tumor-immune model to predict patient response to treatment using NLR as a biomarker and simulates optimal therapies for virtual RCC patients.

bioRxiv · Feb 28, 2019 · PreprintCancer Biology