A. A. Brakhage

Bacteria-induced activation of a fungal silent gene cluster is controlled by histone deacetylase Sirtuin E

This study identifies SirE as a negative regulator of bacteria-induced activation of the ors gene cluster in Aspergillus nidulans, showing that its deletion allows gene cluster activation without bacterial presence.

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis

The paper identifies conidial surface proteins in Aspergillus fumigatus and shows their role in immune evasion during infection.

The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins

This study shows that the Drosophila Toll pathway and specific Bomanins enhance resilience to Aspergillus mycotoxins by mitigating toxin effects rather than directly killing pathogens.

Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome.

This study investigates the role of RNA interference in Aspergillus fumigatus by analyzing genetic variation and functional outcomes of RNAi component knockouts.

Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen

This study identifies HscA as an effector protein from Aspergillus fumigatus that redirects phagosomes to the recycling expulsion pathway by anchoring p11, affecting susceptibility to invasive pulmonary aspergillosis.

Ubiquitous bacterial polyketides induce cross-kingdom microbial interactions

The paper identifies arginine-derived polyketides as bacterial signals that induce natural product production in fungi, revealing cross-kingdom microbial interactions in soil ecosystems.

CORK1, a LRR-Malectin Receptor Kinase for Cellooligomer Perception in Arabidopsis thaliana

This study identifies CORK1 as a receptor kinase in Arabidopsis that detects cellulose breakdown products, triggering Ca2+-dependent responses and immune-related signaling.

The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus

This study shows that stomatin is necessary for dectin-1 accumulation in phagosomal membranes and for macrophage activity against Aspergillus fumigatus.

PLB-985 neutrophil-like cells as a model to study Aspergillus fumigatus pathogenesis

This paper demonstrates that differentiated PLB-985 cells can model key aspects of A. fumigatus interactions with human neutrophils, including phagocytosis, extracellular trap release, and antifungal vesicle production.

Cooperative DNA base and shape recognition by the CCAAT-binding complex and its bZIP transcription factor HapX

This study reports two crystal structures of the CBC-HapX complex bound to DNA, revealing how HapX interacts with DNA and the CBC to regulate gene expression in fungi.

The termite fungal cultivar Termitomyces combines diverse enzymes and oxidative reactions for plant biomass conversion

This paper identifies redox mechanisms in Termitomyces fungi that contribute to lignin degradation in termite symbiosis, revealing a combination of white- and brown-rot strategies.

Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection

This study identifies 314 surface proteins of Aspergillus fumigatus using biotinylation and LC-MS/MS, proposing them as potential diagnostic and therapeutic targets.

The dynamic surface proteomes of allergenic fungal conidia

This study identifies dynamic surface and secreted proteins of Aspergillus fumigatus conidia under different conditions and compares them to other allergenic molds.

Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

This study identifies antifungal extracellular vesicles (afEVs) released by human neutrophils in response to Aspergillus fumigatus, which associate with fungal cells and reduce growth through antimicrobial cargo.

Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections

This study shows that flotillin-dependent lipid rafts are essential for phagolysosomal function against fungal infections, with implications for human susceptibility to aspergillosis.