Author

C. D. Kaplan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Qiu· 3 shared B. Dutagaci· 2 shared M. Feig· 2 shared A. E. Cohen· 1 shared A. Lyubimov· 1 shared A. T. Griffin· 1 shared B. A. Garcia· 1 shared B. Duan· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

C. Qiu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 A using a free-electron laser

L. Guowu, C. O. Barnes, S. Weiss, B. Dutagaci, C. Qiu, M. Feig, A. Lyubimov, J. Song, A. E. Cohen, C. D. Kaplan, G. Calero

This paper presents the structure of ATP-bound RNA Polymerase II at 3.0 Å resolution using a free-electron laser, revealing new insights into substrate binding and metal coordination in the active site.

bioRxiv · Sep 22, 2023 · PreprintBiophysics

Characterization of RNA Polymerase II Trigger Loop Mutations using Molecular Dynamics Simulations and Machine Learning

B. Dutagaci, B. Duan, C. Qiu, C. D. Kaplan, M. Feig

This study uses molecular dynamics and machine learning to analyze RNA Polymerase II trigger loop mutations, finding that ML can predict phenotypes from sequences and MD data reveals structural changes linked to mutation effects.

bioRxiv · Aug 11, 2022Biophysics

Structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in Nucleotide Excision Repair

T. van Eeuwen, Y. Shim, H. J. Kim, T. Zhao, S. Basu, C. D. Kaplan, B. A. Garcia, J. H. Min, K. Murakami

The paper presents a cryo-EM structure of an NER initiation complex involving Rad4-Rad23-Rad33 and TFIIH bound to a DNA lesion, revealing DNA unwinding and translocation mechanisms.

bioRxiv · Jan 14, 2021Biophysics

A genome wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity

N. M. Garza, A. T. Griffin, M. Zulkifli, C. Qiu, C. D. Kaplan, V. M. Gohil

bioRxiv · Dec 31, 2020Biochemistry