Author

C. J. Wong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

A.-C. Gingras· 3 shared E. Tsekitsidou· 2 shared J. T. Wang· 2 shared M. S. Cyert· 2 shared T. Stearns· 2 shared A. D. Portnoff· 1 shared B. Ekechukwu· 1 shared B. J. A. Dyakov· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

A.-C. Gingras

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

High resolution cryo-EM of V-ATPase in native synaptic vesicles

C. E. Coupland, R. Karimi, S. A. Bueler, Y. Liang, G. M. Courbon, J. M. Di Trani, C. J. Wong, R. Saghian, J.-Y. Youn, L.-Y. Wang, J. L. Rubinstein

The paper determines the high-resolution structure of V-ATPase in native synaptic vesicles using cryo-EM, revealing interactions with cholesterol and synaptophysin.

bioRxiv · Apr 1, 2024Biochemistry

Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition

T. L. Pavankumar, C. J. Wong, Y. K. Wong, M. Spies, S. C. Kowalczykowski

The paper investigates how RecBn loads RecA onto ssDNA via a χ-dependent mechanism, showing that RecBn can function independently of its flexible linker.

bioRxiv · May 14, 2023Biochemistry

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 using Proximity Labeling and Affinity Purification

C. M. Aprosoff, B. J. A. Dyakov, V. H. W. Cheung, C. J. Wong, M. Palandra, A.-C. Gingras, H. D. M. Wyatt

This study maps the human SLX4 interactome using BioID and AP-MS, identifying 237 high-confidence interactors and revealing new pathways involved in DNA repair and other cellular processes.

bioRxiv · Sep 19, 2022 · PreprintBiochemistry

Calcineurin associates with centrosomes and regulates cilia length maintenance

E. Tsekitsidou, J. T. Wang, C. J. Wong, I. Ulengin-Talkish, T. Stearns, A.-C. Gingras, M. S. Cyert

This study identifies calcineurin's association with centrosomes and its role in regulating cilia length maintenance through interaction with POC5.

bioRxiv · Jun 16, 2022 · PreprintCell Biology

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

J.-H. Tian, N. Patel, R. Haupt, H. Zhou, S. Weston, H. Hammond, J. Lague, A. D. Portnoff, J. Norton, M. Guebre-Xabier, B. Zhou, K. Jacobson, S. Maciejewski, R. Khatoon, M. Wisniewska, , G. Smith

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

bioRxiv · Jun 29, 2020Microbiology

Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling

C. P. Wigington, J. Roy, N. P. Damle, V. K. Yadav, C. Blikstad, E. Resch, C. J. Wong, D. R. Mackay, J. T. Wang, I. Krystkowiak, D. A. Bradburn, E. Tsekitsidou, S. H. Hong, M. A. Kaderali, S.-l. Xu, , M. S. Cyert

The paper identifies calcineurin (CN) substrates and interactors using a combination of experimental and computational methods, revealing novel roles for CN in regulating nuclear pore complex proteins.

bioRxiv · Mar 26, 2020Cell Biology