Author

C. E. Shannon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. Norton· 3 shared M. Fourcaudot· 3 shared J. P. Palavicini· 2 shared T. M. Bakewell· 2 shared X. Han· 2 shared A. Khattab· 1 shared C. R. Malloy· 1 shared E. S. Jin· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

L. Norton

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Author profile →

3 papers

Recent·Most cited

Persistent Inflammatory Lipotoxicity Impedes Pancreatic β-cell Function in Diet-Induced Obese Mice Despite Correction of Glucotoxicity

I. A. Valdez, J. P. Palavicini, T. M. Bakewell, M. Fourcaudot, I. Ayala, Z. Xu, A. Khattab, X. Han, C. E. Shannon, L. Norton

This study shows that even after correcting hyperglycemia, persistent lipotoxicity from arachidonic acid and lysophosphatidylcholine impairs β-cell function in diet-induced obese mice.

bioRxiv · May 31, 2022 · PreprintPhysiology

Hepatic Mitochondrial Remodeling is Mechanistically Linked to Insulin Resistance in Nonalcoholic Fatty Liver Disease

C. E. Shannon, M. Ragavan, J. P. Palavicini, M. Fourcaudot, T. Bakewell, E. S. Jin, C. R. Malloy, X. Han, M. E. Merritt, L. Norton

This study links insulin resistance and mitochondrial remodeling in NAFLD, showing that insulin sensitization improves mitochondrial function without reducing lipid content.

bioRxiv · Jan 2, 2020Biochemistry

The Metabolic Effects of Angiopoietin-like protein 8 (ANGPLT8) are Differentially Regulated by Insulin and Glucose in Adipose Tissue and Liver and are Controlled by AMPK Signaling

L. Zhang, C. E. Shannon, T. M. Bakewell, M. Abdul-Ghani, M. Fourcaudot, L. Norton

This study investigates the metabolic role of ANGPTL8 in mice, showing improved glucose tolerance and reduced triglycerides, with insulin and glucose having distinct regulatory effects in liver and adipose tissue.

bioRxiv · Aug 15, 2019Physiology