Author

C. R. Malloy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:metabolomics· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

D. Do· 2 shared E. S. Jin· 2 shared F. Cai· 2 shared H. S. Vu· 2 shared L. Cai· 2 shared M. E. Merritt· 2 shared R. J. DeBerardinis· 2 shared S. Kelekar· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

D. Do

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Author profile →

3 papers

Recent·Most cited

Mitochondrial metabolism in primary and metastatic human kidney cancers

D. Bezwada, R. J. DeBerardinis, N. P. Lesner, B. Brooks, H. S. Vu, Z. Wu, L. Cai, S. Kasitinon, S. Kelekar, F. Cai, A. B. Aurora, M. Patrick, A. Leach, R. Ghandour, Y. Zhang, , V. Margulis

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

bioRxiv · Feb 6, 2023Cancer Biology

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

F. Cai, D. J. Bezwada, L. Cai, R. Mahar, Z. Wu, P. Pachnis, C. Yang, S. Kelekar, W. Gu, H. S. Vu, T. P. Mathews, L. G. Zacharias, M. Martin-Sandoval, D. Do, K. C. Oaxaca, , R. J. DeBerardinis

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

bioRxiv · Jul 31, 2022Biochemistry

Hepatic Mitochondrial Remodeling is Mechanistically Linked to Insulin Resistance in Nonalcoholic Fatty Liver Disease

C. E. Shannon, M. Ragavan, J. P. Palavicini, M. Fourcaudot, T. Bakewell, E. S. Jin, C. R. Malloy, X. Han, M. E. Merritt, L. Norton

This study links insulin resistance and mitochondrial remodeling in NAFLD, showing that insulin sensitization improves mitochondrial function without reducing lipid content.

bioRxiv · Jan 2, 2020Biochemistry