Author

T. A. Graubert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

M. J. Walter· 2 shared A. Heard· 1 shared A. J. Frontier· 1 shared A. J. MacRae· 1 shared A. Khanna· 1 shared B. A. Wadugu· 1 shared C. A. Miller· 1 shared C. F. Feeney· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. J. Walter

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Author profile →

2 papers

Recent·Most cited

U2AF1 is a haplo-essential gene required for cancer cell survival

B. A. Wadugu, A. Heard, S. N. Srivatsan, M. O. Alberti, M. Ndonwi, J. Bradley, J. Shao, T. Ahmed, C. L. Shirai, A. Khanna, D. L. Fei, C. A. Miller, T. A. Graubert, M. J. Walter

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Journal of Clinical Investigation · Nov 1, 2021Peer-reviewedCancer Biology

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

R. Chatrikhi, C. F. Feeney, M. J. Pulvino, G. Alachouzos, A. J. MacRae, Z. Falls, S. Rai, W. W. Brennessel, J. L. Jenkins, M. J. Walter, T. A. Graubert, R. Samudrala, M. S. Jurica, A. J. Frontier, C. L. Kielkopf

The paper identifies a small molecule that inhibits pre-mRNA splicing by stabilizing an early-stage U2AF2-RNA complex, offering a new strategy for targeting spliceosome assembly.

bioRxiv · Sep 28, 2020Biochemistry