I. L. Brito

Detailed Social Network Interactions and Gut Microbiome Strain-Sharing Within Isolated Honduras Villages

The paper investigates how social network interactions influence microbiome composition in isolated Honduran villages using social network and microbiome sequencing data.

Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases

The paper identifies gut microbiota-associated bile salt hydrolases (BSHs) with distinct substrate preferences using chemoproteomic profiling.

Microbiome-induced Increases and Decreases in Bone Tissue Strength can be Initiated After Skeletal Maturity

This study shows that altering the gut microbiome in adult mice can reduce or restore bone matrix strength, with sex-specific effects.

Effects of long-term high dose aspartame on body mass, bone strength, femoral geometry, and microbiota composition in a young and aged cohort of male and female mice

Spatial Mapping of Mobile Genetic Elements and their Cognate Hosts in Complex Microbiomes

The paper develops an imaging method to map mobile genetic elements and their bacterial hosts in human oral biofilms, revealing spatial clusters of AMR plasmids and prophage.

Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response

This study shows that STING is required for TLR8-induced IFN production in human monocytes and reveals a new crosstalk mechanism between cytosolic and endosomal innate immune receptors.

Keystone pathobionts associated with colorectal cancer promote oncogenic reprograming

This study identifies how Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis promote oncogenic changes in colorectal cancer by affecting epithelial cells and immune responses.

Coarse-grained Modeling and Experimental Investigation of the Viscoelasticity of Human Gut Mucus and Nanoparticle Dynamics

This study experimentally characterizes human gut mucus viscoelasticity and develops a model to study nanoparticle dynamics influenced by mucin cross-linking and concentration.

Evolution of promoter-proximal pausing enabled a new layer of transcription control

The paper investigates the evolutionary emergence of RNA polymerase II pausing and its regulatory role across species.

Inflammatory bowel disease-associated gut commensals degrade components of the extracellular matrix

This study shows gut commensals degrade extracellular matrix components in vitro and links this activity to IBD progression through proteolytic and enzymatic mechanisms.

Run-on sequencing reveals nascent transcriptomics of the human microbiome

This study applies PRO-seq to the human microbiome to profile nascent transcription, revealing taxon-specific RNAP pause motifs and concurrent transcription and cleavage of guide RNAs and tRNA fragments.

Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR

The paper introduces OIL-PCR to link plasmid-encoded ARGs to bacterial hosts in complex communities, identifying novel associations in a clinical setting.

Pangenome sequence evolution within human gut microbiomes is explained by gene-specific rather than host-specific selective pressures

The paper investigates selective pressures on mobile genes in human gut microbiomes, finding gene-specific selection dominates over host-specific pressures on short time scales.

Transmission of human-associated microbiota along family and social networks

The paper examines bacterial transmission in gut and oral microbiomes of a closed cohort in Fiji, finding weak but significant transmission within households and between spouses using strain-level data.