Author

C. Gaughan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Asthana· 2 shared R. H. Silverman· 2 shared A. Chiang· 1 shared A. Kalinousky· 1 shared C. Ott· 1 shared C. Shamul· 1 shared D. Berke· 1 shared D. Guiggey· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

A. Asthana

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L

J. Xi, G. Snieckute, A. Asthana, C. Gaughan, S. Bekker-Jensen, R. H. Silverman

This study shows that RNase L activation by 2-5A triggers a ZAK-dependent ribotoxic stress response, leading to inflammatory gene transcription and apoptosis.

bioRxiv · Oct 12, 2023Immunology

Linking collective migration/growth to differentiation boosts global shaping of the transcriptome and exhibits a grasshopper effect for driving maturation

O. Ogoke, D. Guiggey, A. Chiang, S. Thompson, T. H. A. Nguyen, D. Berke, C. Ott, A. Kalinousky, C. Shamul, P. Chen, S. Ross, Z. Chen, P. Srivastava, C. Gaughan, S. D. Mahajan, , N. Parashurama

The paper links collective migration to differentiation in hPSC-derived hepatocytes, showing a significant increase in maturation through a deep-learning gene circuit.

bioRxiv · Jul 24, 2022 · PreprintBioengineering

Specificity and Mechanism of Coronavirus, Rotavirus and Mammalian Two-Histidine-Phosphoesterases That Antagonize Antiviral Innate Immunity

A. Asthana, C. Gaughan, S. R. Weiss, R. H. Silverman

This study investigates the biochemical activities and evolutionary relationships of 2,5-oligoadenylate-degrading enzymes from coronaviruses, rotaviruses, and mammalian AKAP7, revealing their role in antagonizing antiviral innate immunity.

bioRxiv · Jun 16, 2021Microbiology