Author

R. H. Silverman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

S. R. Weiss· 4 shared A. Asthana· 3 shared B. Dong· 2 shared C. Gaughan· 2 shared A. R. Fehr· 1 shared C. E. Comar· 1 shared C. J. Otter· 1 shared C. Ye· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

S. R. Weiss

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

C. J. Otter, N. Bracci, N. A. Parenti, C. Ye, T. Li Hui, A. Asthana, J. J. Pfannenstiel, N. Jackson, A. R. Fehr, R. H. Silverman, N. A. Cohen, L. Martinez-Sobrido, S. R. Weiss

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

Proceedings of the National Academy of Sciences · Apr 3, 2024Peer-reviewedMicrobiology

Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L

J. Xi, G. Snieckute, A. Asthana, C. Gaughan, S. Bekker-Jensen, R. H. Silverman

This study shows that RNase L activation by 2-5A triggers a ZAK-dependent ribotoxic stress response, leading to inflammatory gene transcription and apoptosis.

bioRxiv · Oct 12, 2023Immunology

Specificity and Mechanism of Coronavirus, Rotavirus and Mammalian Two-Histidine-Phosphoesterases That Antagonize Antiviral Innate Immunity

A. Asthana, C. Gaughan, S. R. Weiss, R. H. Silverman

This study investigates the biochemical activities and evolutionary relationships of 2,5-oligoadenylate-degrading enzymes from coronaviruses, rotaviruses, and mammalian AKAP7, revealing their role in antagonizing antiviral innate immunity.

bioRxiv · Jun 16, 2021Microbiology

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

Y. Li, D. Renner, C. E. Comar, J. Whelan, H. Reyes, F. L. Cardenas-Diaz, R. Truitt, L. H. Tan, B. Dong, K. D. Alysandratose, J. Huang, J. N. Palmer, N. D. Adappa, M. A. Kohanski, D. N. Kotton, , S. R. Weiss

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

bioRxiv · Sep 24, 2020Microbiology

The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production

J. N. Whelan, J. Hatterschide, D. M. Renner, B. Dong, R. H. Silverman, S. R. Weiss

This study shows RNase L supports ZIKV replication factory formation, enhancing infectious virus production, but inhibits other flaviviruses like dengue and West Nile.

bioRxiv · Nov 24, 2019 · PreprintMicrobiology