Author

A. Asthana

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

R. H. Silverman· 3 shared C. Gaughan· 2 shared S. R. Weiss· 2 shared A. Ferguson· 1 shared A. Li· 1 shared A. R. Fehr· 1 shared B. S. Stern· 1 shared C. J. Otter· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

R. H. Silverman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling

C. J. Otter, N. Bracci, N. A. Parenti, C. Ye, T. Li Hui, A. Asthana, J. J. Pfannenstiel, N. Jackson, A. R. Fehr, R. H. Silverman, N. A. Cohen, L. Martinez-Sobrido, S. R. Weiss

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.

Proceedings of the National Academy of Sciences · Apr 3, 2024Peer-reviewedMicrobiology

Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L

J. Xi, G. Snieckute, A. Asthana, C. Gaughan, S. Bekker-Jensen, R. H. Silverman

This study shows that RNase L activation by 2-5A triggers a ZAK-dependent ribotoxic stress response, leading to inflammatory gene transcription and apoptosis.

bioRxiv · Oct 12, 2023Immunology

Specificity and Mechanism of Coronavirus, Rotavirus and Mammalian Two-Histidine-Phosphoesterases That Antagonize Antiviral Innate Immunity

A. Asthana, C. Gaughan, S. R. Weiss, R. H. Silverman

This study investigates the biochemical activities and evolutionary relationships of 2,5-oligoadenylate-degrading enzymes from coronaviruses, rotaviruses, and mammalian AKAP7, revealing their role in antagonizing antiviral innate immunity.

bioRxiv · Jun 16, 2021Microbiology

Development of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics: a Proof of Concept Investigation

V. Asthana, B. S. Stern, Y. Tang, P. Bugga, A. Li, A. Ferguson, A. Asthana, G. Bao, R. A. Drezek

This paper introduces a novel class of self-assembling dsRNA therapeutics that target specific oncogenic sequences and induce apoptosis in cancer cells.

bioRxiv · Apr 22, 2020Bioengineering