Author

S. Bekker-Jensen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

A. Asthana· 1 shared A. C. Vind· 1 shared A. Kotlyarov· 1 shared A. M. Del Val· 1 shared C. Chauhan· 1 shared C. Gaughan· 1 shared E. Meunier· 1 shared F. L. Zhong· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

A. Asthana

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Author profile →

3 papers

Recent·Most cited

Initiation of a ZAKa-dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease RNase L

J. Xi, G. Snieckute, A. Asthana, C. Gaughan, S. Bekker-Jensen, R. H. Silverman

This study shows that RNase L activation by 2-5A triggers a ZAK-dependent ribotoxic stress response, leading to inflammatory gene transcription and apoptosis.

bioRxiv · Oct 12, 2023Immunology

Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells

F. L. Zhong, P. Rozario, M. Pinilla, A. C. Vind, K. Robinson, T. Gee Ann, M. Jasrie Firdaus, J. Francisco Martinez, L. Zhewang, S. Bekker-Jensen, E. Meunier

This study identifies the mechanism by which nigericin activates the NLRP1 inflammasome in human epithelial cells through potassium efflux and ribotoxic stress response.

bioRxiv · Jun 23, 2023 · PreprintImmunology

PRMT5-mediated regulatory arginine methylation of RIPK3

C. Chauhan, A. M. Del Val, R. Niedenthal, J. V. Olsen, A. Kotlyarov, S. Bekker-Jensen, M. Gaestel, M. B. Menon

This study identifies PRMT5-mediated arginine methylation of RIPK3 as a feedback mechanism regulating RIPK1 activity and function in cell death pathways.

bioRxiv · Aug 1, 2022Cell Biology