M. E. Grigg

Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

Giardia intestinalis reshapes mucosal immunity toward a Type 2 response that attenuates inflammatory bowel-like diseases

This study shows Giardia intestinalis induces a Type 2 immune response that reduces inflammation in the gut, protecting against inflammatory bowel-like diseases.

Extant interspecific hybridization among trematodes within the Schistosoma haematobium species complex in Nigeria

The paper genotypes Schistosoma haematobium eggs from Nigerian communities to identify interspecific hybrids between S. haematobium, S. bovis, and S. curassoni, finding mitonuclear discordance and hybrid diversity in both pastoral and non-pastoral regions.

The commensal protist Tritrichomonas musculus exhibits a dynamic life cycle that induces extensive remodeling of the gut microbiota

This study examines the impact of the commensal protist Tritrichomonas musculus on gut microbiota dynamics in mice, revealing protist-driven microbiome remodeling and distinct life stages of the protist.

Ultrastructural identification and molecular characterization of two new parabasalid species that naturally colonize laboratory mice, Tritrichomonas musculus and Tritrichomonas casperi

The paper identifies and characterizes two new parabasalid species, Tritrichomonas musculus and Tritrichomonas casperi, found in laboratory mice using ultrastructural and molecular methods.

Toxoplasma surface coat protein TgSRS57 (TgSAG3) regulates complement deposition, Factor H recruitment, and promotes parasite persistence

This study shows TgSRS57 regulates complement deposition and Factor H recruitment on Toxoplasma gondii, promoting parasite persistence and disease tolerance.

ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii reveals novel virulence factors implicated in host cell invasion

ToxoNet constructs a high-confidence protein-protein interaction map for Toxoplasma gondii, identifying novel virulence factors involved in host cell invasion.

The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming

This paper shows that Toxoplasma gondii microneme proteins MIC1 and MIC4 bind TLR2 and TLR4 N-glycans to activate innate immune responses and regulate infection outcomes.