Author

C. H. Li

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:cancer & tumor microenvironment· 4 Assay:whole-genome sequencing· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:variant calling· 3

Frequent Co-Authors

P. C. Boutros· 4 shared C. H. Wong· 2 shared ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network· 2 shared K.-F. To· 2 shared Q. He· 2 shared S. Haider· 2 shared Y. Chen· 2 shared A. Wilm· 1 shared

Activity by Year

2017-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersCancer Biology

P. C. Boutros

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Author profile →

7 papers

Recent·Most cited

Ancestry Influences on the Molecular Presentation of Tumours

C. H. Li, S. Haider, P. C. Boutros

This study examines how ancestry affects the mutational landscape of tumors across 12,774 samples, finding ancestry influences mutation counts, timing, and specific mutational signatures.

bioRxiv · Aug 2, 2020 · PreprintCancer Biology

Age Influences on the Molecular Presentation of Tumours

C. H. Li, S. Haider, P. C. Boutros

This study examines how age affects the mutational landscape of tumors across 35 cancer types, revealing age-related differences in mutation numbers, timing, and clinical outcomes.

bioRxiv · Jul 7, 2020Cancer Biology

Ectopic HOTTIP Expression Induces Non-canonical Transactivation Pathways to Promote Growth and Invasiveness in Pancreatic Ductal Adenocarcinoma

C. H. Wong, C. H. Li, Q. He, S. L. Chan, J. H.-M. Tong, K.-F. To, Y. Chen

This study identifies HOTTIP's role in promoting pancreatic ductal adenocarcinoma through both canonical HOXA13-mediated and non-canonical WDR5-MLL1-H3K4me3 pathways.

bioRxiv · Oct 21, 2019Cancer Biology

The Establishment of CDK9/ RNA PolII/H3K4me3/DNA Methylation Feedback Promotes HOTAIR Expression by RNA Elongation Enhancement in Cancer

C. H. Wong, C. H. Li, Q. He, J. H. M. Tong, K.-F. To, Y. Chen

The paper identifies a positive feedback loop involving CDK9, histone modification, and DNA methylation that enhances HOTAIR expression through transcription elongation in cancer.

bioRxiv · Oct 21, 2019Cancer Biology

Divergent mutational processes distinguish hypoxic and normoxic tumours

V. Bhandari, C. H. Li, R. G. Bristow, P. C. Boutros, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network

This study identifies hypoxia-associated mutational processes and genomic features across 1,188 tumours from 27 cancer types, showing hypoxia increases mutational load and influences driver mutations and evolutionary trajectories.

bioRxiv · Jan 28, 2019Cancer Biology

Sex Differences in Oncogenic Mutational Processes

C. H. Li, S. D. Prokopec, R. X. Sun, F. Yousif, N. Schmitz, P. C. Boutros, PCAWG Molecular Subtypes and Clinical Correlates Working Group, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network

This study analyzes sex differences in whole genome mutational processes across 1,983 tumors from 28 subtypes, revealing sex-biased mutations in coding and non-coding regions and mutational signatures.

bioRxiv · Jan 28, 2019Cancer Biology

Single-Virion Sequencing Of Lamivudine Treated HBV Populations Reveal Population Evolution Dynamics And Demographic History

Y. O. Zhu, P. P. Aw, P. F. de Sessions, S. Hong, L. X. See, L. Z. Hong, A. Wilm, C. H. Li, S. Hue, S. G. Lim, N. Nagarajan, W. F. Burkholder, M. Hibberd

This study uses single-virion sequencing to analyze HBV population dynamics in treated patients, revealing selective sweeps and demographic history.

bioRxiv · Apr 20, 2017Evolutionary Biology