Author

C. J. Buchanan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. G. Davis· 3 shared L. P. Deimel· 3 shared Q. J. Sattentau· 3 shared A. J. Baldwin· 2 shared A. Khan· 2 shared G. Sun· 2 shared J. Naismith· 2 shared L. Moynie· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

B. G. Davis

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Author profile →

3 papers

Recent·Most cited

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

L. P. Deimel, L. Moynie, G. Sun, V. Lewis, A. Turner, C. J. Buchanan, S. A. Burnap, C. M. Kobras, M. Stracy, W. B. Struwe, A. J. Baldwin, J. Naismith, B. G. Davis, Q. J. Sattentau

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

bioRxiv · Nov 2, 2023 · PreprintImmunology

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

L. P. Deimel, X. Xue, A. Khan, L. Moynie, C. J. Buchanan, G. Sun, R. McBride, H. Schuster, C. Gauthier, R. Saliba, K. Leonavicius, L. Minall, G. Bort, R. A. Russell, E. Sezgin, , Q. J. Sattentau

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

bioRxiv · Jun 3, 2023 · PreprintImmunology

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

C. J. Buchanan, B. Gaunt, P. J. Harrison, Y. Yang, J. Liu, A. Khan, A. M. Giltrap, A. Le Bas, P. N. Ward, K. Gupta, M. Dumoux, S. Daga, N. Picchiotti, M. Baldassarri, E. Benetti, , B. G. Davis

This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.

bioRxiv · Apr 14, 2021Biophysics