Author

J. Naismith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. J. Baldwin· 2 shared B. G. Davis· 2 shared C. J. Buchanan· 2 shared G. Sun· 2 shared L. Moynie· 2 shared L. P. Deimel· 2 shared Q. J. Sattentau· 2 shared A. Khan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

A. J. Baldwin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

L. P. Deimel, L. Moynie, G. Sun, V. Lewis, A. Turner, C. J. Buchanan, S. A. Burnap, C. M. Kobras, M. Stracy, W. B. Struwe, A. J. Baldwin, J. Naismith, B. G. Davis, Q. J. Sattentau

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

bioRxiv · Nov 2, 2023 · PreprintImmunology

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

L. P. Deimel, X. Xue, A. Khan, L. Moynie, C. J. Buchanan, G. Sun, R. McBride, H. Schuster, C. Gauthier, R. Saliba, K. Leonavicius, L. Minall, G. Bort, R. A. Russell, E. Sezgin, , Q. J. Sattentau

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

bioRxiv · Jun 3, 2023 · PreprintImmunology

Structure of the ForT/PRPP complex uncovers the mechanism of C-C bond formation in C-nucleotide antibiotic biosynthesis

S. Gao, A. Radadiya, W. Li, H. Liu, W. Zhu, V. de Crecy-Lagard, N. Richards, J. Naismith

The paper reports the structure of the ForT/PRPP complex and identifies residues critical for catalysis, proposing a mechanism for C-C bond formation in C-nucleotide antibiotic biosynthesis.

bioRxiv · Mar 26, 2020 · PreprintBiochemistry