L. Renia

Extended blood stage sensitivity profiles of Plasmodium vivax to doxycycline and tafenoquine using Plasmodium cynomolgi as a model

The paper uses Plasmodium cynomolgi to determine the delayed antimalarial effects of doxycycline and tafenoquine on P. vivax, finding IC50 values for doxycycline and tafenoquine.

The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular senescence and drug resilience.

This study identifies artemisinin-induced dormant stages of Plasmodium falciparum as exhibiting senescence-like features and drug resistance.

Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile

This study shows chloroquine induces eryptosis in P. falciparum-infected red blood cells, releasing EVs with unique proteomic profiles that may activate immune pathways.

Suppression of Plasmodium MIF-CD74 Signaling Protects Against Severe Malaria

This study shows that blocking Plasmodium MIF-CD74 signaling protects against experimental cerebral malaria by preventing antigen presentation to CD8+ T cells.

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice

This study shows Gas6 promotes ZIKV replication and severity in humans and mice, linking it to neurological complications and congenital malformations.

Neutralizing antibodies from early cases of SARS-CoV-2 infection offer cross-protection against the SARS-CoV-2 D614G variant.

This study shows that antibodies from early SARS-CoV-2 infections neutralize both the original and D614G variants, though neutralizing capacity decreases over time.

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

This study identifies a potent SARS-CoV-2 neutralizing antibody, 5A6, that binds bivalently to two RBDs on the spike protein, showing resistance to key mutations.

Reverse transcription quantitative PCR to detect low density malaria infections

This study evaluates a qRT-PCR method for detecting low density malaria infections with reduced sample volume compared to uPCR, showing improved sensitivity and specificity in a Myanmar cohort.

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

The paper identifies two immunodominant linear epitopes on the SARS-CoV-2 spike protein that are targets of potent neutralizing antibodies in convalescent patient sera.

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients

The paper identifies differential linear B-cell epitopes to distinguish Zika and Dengue virus infections, showing high sensitivity and specificity in patient samples.