M. M. Fischer

Vaccination by single dose sporozoite injection of blood stage attenuated malaria parasites

The paper identifies slow-growing, avirulent malaria parasite mutants that protect against disease after challenge with wild-type parasites.

On minimising tumoural growth under treatment resistance

This paper develops mathematical models to optimize cancer treatment protocols by analyzing genetic and epigenetic resistance, showing that an optimal protocol can achieve curative treatment in xenograft experiments.

On tumoural growth and treatment under cellular dedifferentiation

This study extends a mathematical model of cancer stem cell-driven tumor growth to include dedifferentiation, showing it increases tumorigenesis and growth speed, and can lead to treatment evasion.

Oncogenic signalling is coupled to colorectal cancer cell differentiation state

This study shows oncogenic signalling in colorectal cancer is linked to cell differentiation states through a defined axis, with mutations affecting stemness and differentiation.

Maintaining and escaping feedback control in hierarchically organised tissue: a case study of the intestinal epithelium

The paper presents a mathematical model of intestinal epithelium dynamics showing how feedback control maintains homeostasis and enables recovery from perturbations.

Hospital use of antibiotics as the main driver of infections with antibiotic-resistant bacteria - a reanalysis of recent data from the European Union

This study reanalyzes EU data to find that hospital antibiotic use is a stronger driver of antibiotic resistance than human or veterinary use.