Author

R. Amino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

P. Formaglio· 4 shared A. B. Fisher· 1 shared A. R. Teixeira· 1 shared A. Scherf· 1 shared B. Franke-Fayard· 1 shared B. Perez-Cabezas· 1 shared C. E. Chitnis· 1 shared C. Funaya· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersMicrobiology

P. Formaglio

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Need for CD8 T cell clusters to eliminate a malaria liver stage arises in part due to heterogeneity in killing efficacy of individual effector T cells

S. Bera, R. Amino, I. A. Cockburn, V. V. Ganusov

The paper uses intravital microscopy to analyze CD8 T cell clusters and their killing efficacy against malaria liver-stage parasites, finding significant variability in parasite elimination.

bioRxiv · May 18, 2022Immunology

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

M. P. Wagner, P. Formaglio, O. Gorgette, J. M. Dziekan, C. Huon, I. Berneburg, S. Rahlfs, J.-C. Barale, S. I. Feinstein, A. B. Fisher, D. Menard, Z. Bozdech, R. Amino, L. Touqui, C. E. Chitnis

This study shows that human PRDX6 is essential for malaria parasite survival by repairing lipid peroxidation damage and that inhibiting it can kill parasites, including artemisinin-resistant strains.

bioRxiv · Apr 11, 2022Cell Biology

Downregulation of the secreted protein with an altered thrombospondin repeat (SPATR) impacts the infectivity of malaria sporozoites

D. M. Costa, M. Sa, A. R. Teixeira, B. Perez-Cabezas, S. Golba, H. Sefiane-Djemaoune, P. Formaglio, B. Franke-Fayard, C. J. Janse, R. Amino, J. Tavares

This study shows that downregulating SPATR in malaria sporozoites impairs their motility, salivary gland invasion, and infectivity to mice.

bioRxiv · Mar 6, 2022 · PreprintMicrobiology

Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity

S. Belhimeur, S. Briquet, R. Peronet, J. Pham, P.-H. Commere, P. Formaglio, R. Amino, A. Scherf, O. Silvie, S. MECHERI

This study shows that Plasmodium parasites engineered to express murine IL-6 fail to progress to blood stage infection and induce long-lasting CD8+ T cell-mediated immunity.

bioRxiv · Nov 16, 2021Immunology

Malaria transmission relies on concavin-mediated maintenance of Plasmodium sporozoite cell shape

J. Kehrer, P. Formaglio, J. M. Muthinja, S. Weber, D. Baltissen, C. Lance, J. Ripp, J. Grech, M. Meissner, C. Funaya, R. Amino, F. Frischknecht

This study identifies concavin as a protein essential for maintaining Plasmodium sporozoite shape during mosquito transmission and skin migration, with its absence leading to shape defects and reduced transmission efficiency.

bioRxiv · Nov 6, 2021 · PreprintMicrobiology