Author

C. J. Kupitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:structural biology· 4 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1 Organism:virus· 1

Frequent Co-Authors

M. S. Hunter· 4 shared B. Hayes· 3 shared E. Ayan· 3 shared E. Destan· 3 shared E. H. Dao· 3 shared F. B. Ertem· 3 shared M. Liang· 3 shared R. G. Sierra· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

M. S. Hunter

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4 papers

Recent·Most cited

4D Crystallography Captures Transient IF1-Ribosome Dynamics in Translation Initiation

I. Yapici, E. H. Dao, S. Yokoi, E. Destan, E. Ayan, A. Shafiei Kamel, F. B. Ertem, C. Kulakman, M. Yilmaz, B. Tosun, H. Ciftci, A. Kepceoglu, J. A. Johnson, O. Guven, A. Ergul, , H. DeMirci

This study uses 4D crystallography to capture transient dynamics of IF1 binding to the 30S ribosomal subunit, revealing allostery and interactions during translation initiation.

bioRxiv · Oct 27, 2023 · PreprintBiophysics

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography

B. Tosun, Y. Rao, E. Destan, E. H. Dao, F. B. Ertem, M. Yilmaz, I. Yapici, M. Gul, E. Ayan, J. A. Johnson, A. Shafiei, C. Kulakman, B. Hayes, M. Liang, C. H. Yoon, , H. DeMirci

This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.

bioRxiv · Oct 24, 2023 · PreprintBiophysics

RNA structures and dynamics with A resolution revealed by x-ray free electron lasers

K. A. Zielinski, S. Sui, S. A. Pabit, D. A. Rivera, T. Wang, Q. Hu, M. M. Kashipathy, S. Lisova, C. B. Schaffer, V. Mariani, M. S. Hunter, C. J. Kupitz, F. R. Moss, F. P. Poitevin, T. D. Grant, L. Pollack

This paper reveals RNA structures and dynamics at near-atomic resolution using x-ray free electron lasers, showing how RNA folds through intermediate states and forms triplexes.

bioRxiv · May 24, 2023Biophysics

Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing

S. Durdagi, C. Dag, B. Dogan, M. Yigin, T. Avsar, C. Buyukdag, I. Erol, F. B. Ertem, S. Calis, G. Yildirim, M. Orhan, O. Guven, B. Aksoydan, E. Destan, K. Sahin, , Sn

The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.

bioRxiv · Sep 9, 2020Biophysics