Author

C. J. Obara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:electronic health records· 1

Frequent Co-Authors

J. Lippincott-Schwartz· 3 shared A. Kreshuk· 1 shared A. S. Moore· 1 shared A. Speiser· 1 shared B. Carragher· 1 shared C. Blackstone· 1 shared C. Kwak· 1 shared C. P. Calderon· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

J. Lippincott-Schwartz

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Author profile →

4 papers

Recent·Most cited

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

K. Nakamura, S. Aoyama-Ishiwatari, T. Nagao, M. Paaran, C. J. Obara, Y. Sakurai-Saito, J. Johnston, Y. Du, S. Suga, M. Tsuboi, M. Nakakido, K. Tsumoto, Y. Kishi, Y. Gotoh, C. Kwak, , Y. Hirabayashi

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

bioRxiv · Aug 22, 2023Cell Biology

Simultaneous photoactivation and high-speed structural tracking reveal diffusion-dominated motion in the endoplasmic reticulum

M. Dora, C. J. Obara, T. Abel, J. Lippincott-Schwartz, D. Holcman

This study uses photoactivation and high-speed imaging with machine learning to show that proteins in the ER exhibit Brownian diffusion, with structural asymmetry influencing their movement.

bioRxiv · Apr 23, 2023 · PreprintCell Biology

Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

C. J. Obara, J. Nixon-Abell, A. S. Moore, F. Riccio, D. P. Hoffman, G. Shtengel, C. S. Xu, K. Schaefer, H. A. Pasolli, J.-B. Masson, H. F. Hess, C. P. Calderon, C. Blackstone, J. Lippincott-Schwartz

This study uses 3D electron microscopy and live cell imaging to reveal dynamic subdomains at ER-mitochondria contact sites and how VAPB tethers contribute to their structure and remodeling.

bioRxiv · Sep 3, 2022 · PreprintCell Biology

Deep learning enables fast and dense single-molecule localization with high accuracy

A. Speiser, L.-R. Müller, U. Matti, C. J. Obara, W. R. Legant, A. Kreshuk, J. H. Macke, J. Ries, S. C. Turaga

This paper introduces DECODE, a deep learning tool that improves single-molecule localization speed and density in SMLM with high accuracy across various imaging conditions.

bioRxiv · Oct 26, 2020Biophysics