J. Nixon-Abell

Quantifying collective interactions in biomolecular phase separation

This study quantifies collective interactions in biomolecular phase separation by analyzing dilute phase concentrations and free energy, revealing how salts and small molecules modulate condensate formation.

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

This study uses 3D electron microscopy and live cell imaging to reveal dynamic subdomains at ER-mitochondria contact sites and how VAPB tethers contribute to their structure and remodeling.

High-fidelity 3D live-cell nanoscopy through data-driven enhanced super-resolution radial fluctuation

This paper introduces eSRRF, an enhanced super-resolution imaging method that improves image fidelity and extends to 3D imaging using multi-focus microscopy.

Tie-lines reveal interactions driving heteromolecular condensate formation

The paper develops a method to determine tie-line gradients in ternary LLPS systems using dilute phase concentration measurements, revealing interaction types and compositions in biomolecular condensates.

Multiphase condensates from a kinetically arrested phase transition

This paper shows that multiphase biomolecular condensates form due to kinetic trapping during phase transitions, not thermodynamic stability, and explains how this leads to internal sub-compartments.

High Resolution Biomolecular Condensate Phase Diagrams with a Combinatorial Microdroplet Platform

This paper introduces a microdroplet platform to rapidly generate high-resolution phase diagrams of biomolecular condensates and demonstrates its application in studying phase transitions.