Author

M. Nakakido

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Organism:human· 3 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1

Frequent Co-Authors

K. Tsumoto· 5 shared D. Kuroda· 4 shared S. Nagatoishi· 4 shared A. Yui· 2 shared S. Uchiyama· 2 shared T. Maruno· 2 shared B. Carragher· 1 shared C. J. Obara· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBiochemistry

K. Tsumoto

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Author profile →

5 papers

Recent·Most cited

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

K. Nakamura, S. Aoyama-Ishiwatari, T. Nagao, M. Paaran, C. J. Obara, Y. Sakurai-Saito, J. Johnston, Y. Du, S. Suga, M. Tsuboi, M. Nakakido, K. Tsumoto, Y. Kishi, Y. Gotoh, C. Kwak, , Y. Hirabayashi

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

bioRxiv · Aug 22, 2023Cell Biology

Conformational features and interaction mechanisms of VHH antibodies with β-hairpin-like CDR-H3: A case of Nb8-HigB2 interaction.

K. Yamamoto, S. Nagatoishi, M. Nakakido, D. Kuroda, K. Tsumoto

This study investigates the conformational features and interaction mechanisms of a β-hairpin-like CDR-H3 in the VHH antibody Nb8, revealing key residues critical for structural stability and binding to HigB2.

bioRxiv · Jul 2, 2023 · PreprintBiochemistry

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene

A. Yui, D. Kuroda, T. Maruno, M. Nakakido, S. Nagatoishi, S. Uchiyama, K. Tsumoto

This study investigates how SNPs in the LI-cadherin gene affect cancer metastasis by weakening cell-cell adhesion through reduced homodimerization and altered hydrogen bonding.

bioRxiv · Oct 2, 2022 · PreprintBiochemistry

Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Rα/glycoprotein 130 signaling complex

C. Mori, S. Nagatoishi, R. Matsunaga, D. Kuroda, M. Nakakido, K. Tsumoto

This study compares the molecular interactions of the IL-11/IL-11R/gp130 complex with IL-6/IL-6R/gp130, revealing differences in thermodynamics and domain involvement that may explain distinct biological functions.

bioRxiv · Jul 14, 2022Biochemistry

Dimerization mechanism and structural features of human LI-cadherin

A. Yui, J. M. M. Caaveiro, D. Kuroda, M. Nakakido, S. Nagatoishi, S. Goda, T. Maruno, S. Uchiyama, K. Tsumoto

This study determines the crystal structure of LI-cadherin EC1-4 homodimer and shows its unique architecture and noncanonical calcium ion-free linker, revealing the mechanism of homodimerization essential for cell adhesion.

bioRxiv · Sep 18, 2020Biochemistry