Author

Y. Gotoh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Organism:E. coli· 3 Assay:metagenomics· 3 Approach:statistical model· 3 Research Focus:clustering· 2

Frequent Co-Authors

T. Hayashi· 5 shared K. Nakamura· 3 shared H. Endo· 2 shared H. Ogata· 2 shared H. Tetsuya· 2 shared K. Nagasaki· 2 shared S. Aoyama-Ishiwatari· 2 shared T. Okazaki· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

T. Hayashi

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity

Y. Fang, L. Meng, J. Xia, Y. Gotoh, T. Hayashi, K. Nagasaki, H. Endo, Y. Okazaki, H. Ogata

This study analyzes giant virus dynamics using metagenomic data, revealing year-round recovery and distinct population dynamics linked to microdiversity and niche breadth.

bioRxiv · Jul 8, 2024Microbiology

Effect of phage variation on Shiga toxin 2 (Stx2) production and the virulence of Stx-producing Escherichia coli

K. Nakamura, H. Nakayama-Imaohji, M. Emmanuel, I. Taniguchi, Y. Gotoh, J. Isobe, K. Kimata, Y. Igawa, T. Kitahashi, Y. Takahashi, R. Nomoto, K. Iwabuchi, Y. Morimoto, S. Iyoda, T. Kuwahara, T. Hayashi

This study examines how variations in Stx2 phages affect Stx2 production and virulence in O145:H28 STEC strains, revealing differences in production levels based on phage type and repressor type.

bioRxiv · Mar 6, 2024 · PreprintMicrobiology

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

K. Nakamura, S. Aoyama-Ishiwatari, T. Nagao, M. Paaran, C. J. Obara, Y. Sakurai-Saito, J. Johnston, Y. Du, S. Suga, M. Tsuboi, M. Nakakido, K. Tsumoto, Y. Kishi, Y. Gotoh, C. Kwak, , Y. Hirabayashi

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

bioRxiv · Aug 22, 2023Cell Biology

Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex

T. M. Frey, T. Murakami, K. Maki, T. Kawaue, A. Sugai, N. Nakazawa, T. Adachi, M. Kengaku, K. Ohki, Y. Gotoh, Y. Kishi

The paper examines age-related changes in nuclear shape dynamics in excitatory neurons of the visual cortex using time-lapse imaging and finds reduced morphological dynamics in aged nuclei.

Aging Cell · Jul 21, 2023Peer-reviewedCell Biology

Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance

M. Miyakoshi, T. Morita, A. Kobayashi, A. Berger, H. Takahashi, Y. Gotoh, T. Hayashi, K. Tanaka

The paper shows that glutamine synthetase mRNA produces an sRNA, GlnZ, which regulates carbon/nitrogen metabolism by repressing SucA expression.

bioRxiv · Jul 25, 2022 · PreprintMicrobiology

Year-round dynamics of amplicon sequence variant communities differ among eukaryotes, Mimiviridae, and prokaryotes in a coastal ecosystem

F. Prodinger, H. Endo, Y. Takano, Y. Li, K. Tominaga, T. Isozaki, R. Blanc-Mathieu, Y. Gotoh, H. Tetsuya, E. Taniguchi, K. Nagasaki, T. Yoshida, H. Ogata

A one-year observation of coastal microbial communities revealed similar but different community dynamics for eukaryotes, a group of large viruses, and prokaryotes.

bioRxiv · Feb 2, 2021 · PreprintMicrobiology

Prophages integrating into prophages: a mechanism to accumulate type III secretion effector genes and duplicate Shiga toxin-encoding prophages in Escherichia coli

K. Nakamura, Y. Ogura, Y. Gotoh, H. Tetsuya

The paper identifies a mechanism where prophages integrate into other prophages in Escherichia coli, leading to the duplication of Shiga toxin-encoding prophages and the accumulation of type III secretion effector genes.

bioRxiv · Nov 4, 2020Microbiology

NUDT21 links mitochondrial IPS-1 to RLR-containing stress granules and activates host antiviral defense

S. Aoyama-Ishiwatari, T. Okazaki, S.-i. Iemura, T. Natsume, Y. Okada, Y. Gotoh

This study shows NUDT21 connects RLRs in stress granules to mitochondrial IPS-1, enabling antiviral defense by facilitating type I IFN induction.

bioRxiv · Apr 9, 2020Immunology

Comprehensive in virio structure probing analysis of the influenza A virus identifies a functional RNA structure involved in replication and segment interactions

N. Takizawa, K. Higashi, R. K. Kawaguchi, Y. Gotoh, Y. Suzuki, T. Hayashi, K. Kurokawa

bioRxiv · Mar 5, 2020 · PreprintMicrobiology

A universal subcuticular bacterial symbiont of a coral predator, the crown-of-thorns starfish, in the Indo-Pacific

N. Wada, H. Yuasa, R. Kajitani, Y. Gotoh, Y. Ogura, D. Yoshimura, A. Toyoda, S.-L. Tang, Y. Higashimura, H. Sweatman, Z. H. Forsman, O. Bronstein, G. Eyal, N. Thongtham, T. Itoh, , N. Yasuda

This study identifies a universal bacterial symbiont, COTS27, found in the subcuticular space of crown-of-thorns starfish across the Indo-Pacific, suggesting an ancient symbiotic relationship.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis

H. Tanaka, T. Okazaki, M. Yokota, M. Koike, Y. Okada, Y. Fujiki, Y. Gotoh

This study shows peroxisomes regulate mitochondrial dynamics and apoptosis by affecting Drp1-mediated fission and caspase activation.

bioRxiv · Sep 3, 2018Cell Biology