Author

C. S. Xu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 9

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Assay:imaging· 5 Organism:mouse· 5 Assay:electronic health records· 3 Organism:human· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

H. F. Hess· 7 shared S. Pang· 6 shared H. A. Pasolli· 5 shared J. Lippincott-Schwartz· 5 shared G. Shtengel· 4 shared M. Freeman· 4 shared M. Solimena· 3 shared A. Müller· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersCell Biology

H. F. Hess

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Structure, interaction, and nervous connectivity of beta cell primary cilia

A. Müller, N. Klena, S. Pang, L. E. G. Garcia, O. Topcheva, S. Aurrecoechea Duran, D. Sulaymankhil, M. Seliskar, H. Mziaut, E. Schöniger, D. Friedland, N. Kipke, S. Kretschmar, C. Münster, J. Weitz, , M. Solimena

This study reveals the structural and spatial organization of beta cell primary cilia in mouse and human islets, showing their interactions with neighboring cells and nerves, and their role in islet connectivity.

bioRxiv · Dec 1, 2023Cell Biology

Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

C. J. Obara, J. Nixon-Abell, A. S. Moore, F. Riccio, D. P. Hoffman, G. Shtengel, C. S. Xu, K. Schaefer, H. A. Pasolli, J.-B. Masson, H. F. Hess, C. P. Calderon, C. Blackstone, J. Lippincott-Schwartz

This study uses 3D electron microscopy and live cell imaging to reveal dynamic subdomains at ER-mitochondria contact sites and how VAPB tethers contribute to their structure and remodeling.

bioRxiv · Sep 3, 2022 · PreprintCell Biology

An open-access volume electron microscopy atlas of whole cells and tissues

C. S. Xu, S. Pang, G. Shtengel, A. Müller, A. T. Ritter, H. K. Hoffman, S.-y. Takemura, Z. Lu, H. A. Pasolli, N. Iyer, J. Chung, D. Bennett, A. V. Weigel, M. Freeman, S. B. van Engelenburg, , H. Hess

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

Nature · Oct 6, 2021Peer-reviewedCell Biology

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

S.-H. Sheu, S. Upadhyayula, V. Dupuy, S. Pang, A. L. Lemire, D. Walpita, H. A. Pasolli, F. Deng, J. Wan, L. Wang, J. Houser, S. Sanchez-Martinez, S. E. Brauchi, S. Banala, M. Freeman, , D. E. Clapham

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

bioRxiv · Sep 27, 2021Cell Biology

High resolution 3D imaging of liver reveals a central role for subcellular architectural organization in metabolism

G. Parlakgul, A. P. Arruda, E. Cagampan, S. Pang, E. Guney, Y. Lee, H. F. Hess, C. S. Xu, G. S. Hotamisligil

The paper uses high-resolution 3D imaging to show that subcellular organization in liver cells changes with obesity, affecting metabolism.

bioRxiv · Nov 18, 2020Cell Biology

Automatic whole cell organelle segmentation in volumetric electron microscopy

L. Heinrich, D. Bennett, D. Ackerman, W. Park, J. Bogovic, N. Eckstein, A. Petruncio, J. Clements, C. S. Xu, J. Funke, W. Korff, H. Hess, J. Lippincott-Schwartz, S. Saalfeld, A. Weigel, C. Project Team

The paper develops an automatic pipeline for segmenting and analyzing organelles in whole cells using FIB-SEM data, enabling quantification of spatial interactions and cross-modality registration.

bioRxiv · Nov 14, 2020 · PreprintCell Biology

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

A. Mueller, D. Schmidt, C. S. Xu, S. Pang, J. V. D'Costa, S. Kretschmar, C. Muenster, T. Kurth, F. Jug, M. Weigert, H. F. Hess, M. Solimena

The paper provides 3D reconstructions of microtubule networks in primary mouse beta cells and shows their role in insulin secretory granule positioning.

bioRxiv · Oct 7, 2020Cell Biology

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

D. P. Hoffman, G. Shtengel, C. S. Xu, K. R. Campbell, M. Freeman, L. Wang, D. E. Milkie, H. A. Pasolli, N. Iyer, J. A. Bogovic, D. R. Stabley, A. Shirinifard, S. Pang, D. Peale, K. Schaefer, , H. F. Hess

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

bioRxiv · Sep 18, 2019Cell Biology

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

C.-L. Chang, A. V. Weigel, M. S. Ioannou, H. A. Pasolli, C. S. Xu, D. R. Peale, G. Shtengel, M. Freeman, H. F. Hess, C. Blackstone, J. Lippincott-Schwartz

This study identifies Spastin's role in tethering lipid droplets to peroxisomes and facilitating fatty acid trafficking via ESCRT-III proteins.

bioRxiv · Feb 14, 2019Cell Biology