S. Schreiber

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

The paper examines the relationship between HK2 expression and inflammation severity in IBD patients using bulk transcriptome data and confirms findings at the cellular and protein levels.

Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes

The paper introduces photo-stereoprobes for expanding the ligandable proteome and demonstrates their use in discovering bioactive small molecules.

Partitioning the Impacts of Spatial-Temporal Variation in Demography and Dispersal on Metapopulation Growth Rates

The paper decomposes metapopulation growth rates into components of spatial-temporal variation in fitness and dispersal, showing how these factors influence population persistence.

Tryptophan wasting and disease activity as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases.

This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

Building modern coexistence theory from the ground up: the role of community assembly

This paper expands modern coexistence theory to species-rich communities by addressing limitations in mutual invasibility conditions and provides a framework for analyzing invasion resistance and coexistence.

Proteomic discovery of chemical probes that perturb protein complexes in human cells

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

ROS induction as a strategy to target persister cancer cells with low metabolic activity in NRAS mutated melanoma

The paper identifies ROS induction as a strategy to target MEK-inhibitor resistant NRAS-mutated melanoma cells by exploiting their quiescent metabolic state and elevated baseline ROS levels.

Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration

This study shows that tobacco smoking causes vascular damage and immune changes linked to neurodegeneration, even in asymptomatic individuals.

Does deterministic coexistence theory matter in a finite world?

This study evaluates how well deterministic coexistence metrics predict species coexistence duration in finite, stochastic environments using experimental data.

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

Coevolution of Patch Selection in Stochastic Environments

The paper analyzes multi-species Lotka-Volterra models to show how environmental stochasticity affects coevolution of patch selection and evolutionary outcomes.

Mast seeding promotes evolution of scatter-hoarding

This study uses a mathematical model to show that mast seeding promotes the evolution of scatter-hoarding by reducing seed pilferage and caching costs during periods of high seed availability.

Complex community-wide consequences of consumer sexual dimorphism

The paper shows that consumer sexual dimorphism can significantly affect resource coexistence, abundance, and dynamics in a two-resource, one-consumer model.

Sick of Eating: eco-evo-immuno dynamics of predators and their trophically acquired parasites

The paper examines eco-evo-immuno dynamics in predators consuming prey with different parasites, finding a potential negative correlation between parasite intake and infection when evolutionary tradeoffs are weak.

Temporally auto-correlated predator attacks structure ecological communities

The paper examines how temporally auto-correlated predator attack rates affect prey coexistence and community structure, showing that positive auto-correlations can enable coexistence through covariance mechanisms.

Novel quaternary structures of the human prion protein globular domain

This study reports a novel dimeric and oligomeric structure of human PrPC's globular domain and explores its structural dynamics and implications for prion conversion.

Stage-mediated priority effects and species life history shape long-term competition dynamics

The paper shows that priority effects in competition depend on species' life history and the number of generations per season, with stronger effects in systems with fewer generations.

Positively and negatively autocorrelated environmental fluctuations have opposing effects on species coexistence

This study shows that positive and negative environmental autocorrelations affect species coexistence differently by altering the conditions for the storage effect and competitive interactions.

Establishing live-cell single-molecule localization microscopy imaging and single-particle tracking in the archaeon Haloferax volcanii

This paper establishes live-cell single-molecule localization microscopy and single-particle tracking in the archaeon Haloferax volcanii by developing a reliable protocol and optimizing fluorescent proteins for imaging.

Is evolution in response to extreme events good for population persistence?

The paper examines how evolution during extreme events affects population persistence, finding that heritability and phenotypic variance influence extinction risk depending on event duration and severity.

Destabilizing evolutionary and eco-evolutionary feedbacks drive empirical eco-evolutionary cycles

The paper identifies how ecological, evolutionary, and eco-evolutionary feedbacks influence system stability using nine empirically-parameterized models of exploiter-victim systems.

Individual variation in dispersal and fecundity increases rates of spatial spread

The paper uses mathematical models to show that individual variation in dispersal and heritability increase population spread rates, while fecundity variation only does so when heritable.

Social information drives ecological outcomes among competing species

The paper shows social information can change competitive outcomes between species by altering extinction risks and promoting coexistence or mutual exclusion based on social signal strengths.

When rarity has costs: coexistence under positive frequency-dependence and environmental stochasticity

This paper analyzes how positive frequency-dependence and environmental stochasticity affect species coexistence through mathematical models.

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion

This study identifies 6-phosphogluconate dehydrogenase (PGD) as essential for ER structural integrity and protein secretion, linking cytosolic carbohydrate metabolism to ECM secretion processes.

Predicting Evolutionarily Stable Strategies fromFunctional Responses of Sonoran Desert Annuals toPrecipitation

The paper models how precipitation variability influences bet-hedging strategies in Sonoran Desert annual plants by analyzing seed survival and reproductive responses.

A chemical biology view of bioactive small molecules and a binder-based approach to connect biology to precision medicines

The paper discusses a chemical biology approach focusing on binder-based compounds to connect biological targets to precision medicines, challenging traditional drug discovery paradigms.

Neolithic and Medieval virus genomes reveal complex evolution of Hepatitis B

This study analyzes three ancient HBV genomes from European skeletons, showing HBV circulation for 7000 years and distinct lineages that may have gone extinct.

Topography and refractometry of sperm cells using SLIM

This study uses SLIM to measure sperm cell thickness and refractive index, finding tail thickness down to 150 nm and refractive index up to 1.6 near the head.