A. Traulsen

Graph-structured populations elucidate the role of deleterious mutations in long-term evolution

The paper investigates how spatial structure affects evolutionary outcomes by identifying amplifier and suppressor graphs for mutant fixation and their impact on long-term fitness.

Reconciling ecology and evolutionary game theory or When not to think cooperation

This paper critiques the assumption in evolutionary game theory that all individuals have equal intrinsic growth rates, highlighting its limitations and suggesting a reconciliation with ecology.

A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide

The paper quantifies phenotypic heterogeneity in glioblastoma cells' response to temozolomide, showing non-genetic factors drive differential drug response.

Infection dynamics in the urinary tract - The importance of non-planktonic phases during early infection and resistance evolution

This study uses a mathematical model to show that non-planktonic bacterial phases in UTIs increase infection risk and shape resistance evolution, with probiotic pretreatment improving antibiotic efficacy.

Evolution of irreversible differentiation under stage-dependent cell differentiation

This paper develops a theoretical model to study how stage-dependent cell differentiation affects the evolution of optimal differentiation patterns, finding that irreversible differentiation is favored in small organisms.

Inferring interactions from microbiome data

The paper introduces a computational workflow to infer microbial community interactions from time series data, quantifying parameter uncertainty and comparing mechanistic models.

Gut-associated functions are favored during microbiome assembly across C. elegans life

This study examines microbiome assembly dynamics in C. elegans, showing increased gut-associated functions and enrichment of specific bacterial genera over the host's lifetime.

Self-loops in Evolutionary Graph Theory: Friends or Foes?

The paper examines the impact of self-loops on evolutionary dynamics in structured populations, showing they are beneficial at low mutation rates but detrimental at intermediate and high rates.

Bacterial c-di-GMP plays a key role in the evolution of host-association

This study shows that c-di-GMP upregulation enables bacteria to adapt to host-association across diverse species.

On the effect of inheritance of microbes in commensal microbiomes

This study models microbial inheritance from parents to offspring and finds it significantly shapes microbiomes in hosts with short lifespans or limited environmental colonization.

Understanding and leveraging phenotypic plasticity during metastasis formation

This study develops a mathematical model to understand how phenotypic plasticity influences metastasis formation and shows it can protect tumors from treatment, suggesting it as a therapeutic target.

Categorising update mechanisms for graph-structured metapopulations

This paper classifies update mechanisms for graph-structured metapopulations to identify commonalities and research gaps.

Promoting extinction or minimizing growth? The impact of treatment on trait trajectories in evolving populations

This study examines how treatment affects trait evolution in populations by analyzing fitness landscapes and adaptation dynamics in birth and death rates.

Do amplifiers of selection maximise average fitness?

The paper investigates whether amplifiers of selection maximize population mean fitness in the steady-state by analyzing the impact of different graph structures on mutant fixation probabilities and fitness outcomes.

Eco-evolutionary dynamics of clonal multicellular life cycles

This study presents a model of colonial life cycles evolution that incorporates group interactions, showing that coexistence of life cycles or initial state dependence can occur, which simpler models without interactions cannot capture.

Evolution of reproductive strategies in incipient multicellularity

The paper develops a population model to analyze optimal reproductive strategies in incipient multicellular organisms, finding that organism size and cellular interaction influence reproductive success.

The effect of microbial selection on the occurrence-abundance patterns of microbiomes

The paper investigates how type-specific rates affect occurrence-abundance patterns in microbial communities using a computational model and finds that large immigration and biodiversity lead to these patterns regardless of neutrality.

Fixation probabilities in network structuredmeta-populations

The paper examines how migration rates and meta-population structure affect fixation probabilities, finding deviations from individual-based network models when patch sizes differ.

Modeling host-associating microbes under selection

The paper models microbial populations in a two-compartment host-environment system to analyze selection pressures on replication and migration rates.

Evolution of irreversible somatic differentiation

This study develops an evolutionary model showing that costly cell differentiation, beneficial vegetative cells, and sufficient organism size are necessary for irreversible somatic differentiation.

The impact of phenotypic heterogeneity of tumour cells on treatment and relapse dynamics

This paper models how phenotypic heterogeneity in cancer cells affects treatment outcomes and relapse, showing that growth rate-dependent therapies delay relapse but may create resistant subpopulations.

Why is cyclic dominance so rare?

The paper investigates why cyclic dominance is rare in nature by showing that it is more likely to emerge when new types are unrelated to existing ones rather than similar.

How long do Red Queen dynamics survive under genetic drift? A comparative analysis of evolutionary and eco-evolutionary models

This study compares evolutionary and eco-evolutionary models of Red Queen dynamics, finding that ecological dynamics and local competition accelerate genotype extinction compared to fixed population size models.

Neutrality in the Metaorganism

This study shows that microbiota community structure across various host organisms aligns with neutral model predictions, suggesting neutral processes rather than host selection primarily shape microbial communities after colonization.

How many samples are needed to infer truly clonal mutations from heterogenous tumours?

This study determines how many samples are needed to accurately infer clonal mutations in heterogeneous tumors by optimizing sampling strategies.

Evolution of simple multicellular life cycles in dynamic environments

This study develops a framework to analyze how simple multicellular life cycles evolve in dynamic environments, finding that deterministic reproduction modes are favored over stochastic ones.

The invasion of de-differentiating cancer cells into hierarchical tissues

This study uses mathematical models to investigate how de-differentiation can be an adaptive mechanism in cellular hierarchies, deriving thresholds for its emergence based on hierarchy properties and de-differentiation patterns.

Interacting cells driving the evolution of multicellular life cycles

This study uses evolutionary game theory to identify optimal life cycles for multicellular evolution, finding that only eight life cycles maximize population growth rate.

Stochastic population dynamics driven by mutant interactors

The paper models population dynamics with mutant interactors that alter interactions between residents and mutants, showing how these interactions affect population size and extinction risk.

Replicative cellular age distributions in compartmentalised tissues

This study examines how progenitor compartments with different self-renewal and differentiation capacities affect replicative cellular age distributions and cancer risk.