Author

C. L. Kleinman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

S. Hebert· 2 shared A. Comba· 1 shared A. J. Nicola Candia· 1 shared A. M. Sonabend· 1 shared A. Mujeeb· 1 shared A. P. Gomes· 1 shared A. Pacis· 1 shared A. Robert· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

S. Hebert

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

I. E. Elkholi, A. Robert, C. Malouf, H. Kuasne, S. Drapela, G. Macleod, S. Hebert, A. Pacis, V. Calderon, C. L. Kleinman, A. P. Gomes, J. A. Aguirre-Ghiso, M. Park, S. Angers, J.-F. Cote

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

bioRxiv · Aug 2, 2023Cancer Biology

H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas

M. B. Garcia Fabiani, S. Haase, K. Banerjee, Z. Zhu, B. McClellan, A. Mujeeb, Y. Li, C. E. Tronrud, M. L. Varela, M. E. J. West, J. Yu, P. Kadiyala, A. Taher, F. J. NUNEZ, M. S. Alghamri, , Sart

This study shows that H3.3-G34R mutations reprogram the tumor immune microenvironment in diffuse hemispheric gliomas, enhancing the efficacy of immune stimulatory gene therapy and leading to long-term survival in treated mice.

bioRxiv · Jun 13, 2023 · PreprintCancer Biology

Satellite cell expansion is mediated by P-eIF2α dependent Tacc3 translation

R. Fujita, G. Lean, S. Jamet, S. Hebert, C. L. Kleinman, C. Crist

This study shows that P-eIF2α-dependent translation of Tacc3 mRNA enables satellite cell expansion and skeletal muscle regeneration.

bioRxiv · May 13, 2020Cell Biology