Author

S. Drapela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. P. Gomes· 3 shared D. Ilter· 2 shared A. Pacis· 1 shared A. Robert· 1 shared B. Kvokackova· 1 shared C. L. Kleinman· 1 shared C. Malouf· 1 shared D. Kurfurstova· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

A. P. Gomes

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity

J. Tejero, R. Hesterberg, S. Drapela, D. Ilter, D. Raizada, F. Lazure, H. Kashfi, M. Liu, J. Fernandez-Garcia, S.-M. Fendt, J. Asara, J. Cleveland, A. P. Gomes

This study shows that methylmalonic acid impairs CD8+ T cell function and promotes tumor growth by inducing metabolic dysfunction and exhaustion.

bioRxiv · Mar 3, 2024Immunology

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

I. E. Elkholi, A. Robert, C. Malouf, H. Kuasne, S. Drapela, G. Macleod, S. Hebert, A. Pacis, V. Calderon, C. L. Kleinman, A. P. Gomes, J. A. Aguirre-Ghiso, M. Park, S. Angers, J.-F. Cote

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

bioRxiv · Aug 2, 2023Cancer Biology

NADK upregulation is an essential metabolic adaptation that enables breast cancer metastatic colonization

D. Ilter, T. Schild, N. Ward, S. Drapela, E. Adhikari, V. Low, E. Le-Lau, G. M. DeNicola, M. McReynolds, A. P. Gomes

This study identifies NADK upregulation as a critical metabolic adaptation enabling breast cancer metastasis by enhancing NADPH production and oxidative stress resistance.

bioRxiv · Mar 25, 2022 · PreprintCancer Biology

Pre-existing cell subpopulations in primary prostate cancers display surface fingerprint of docetaxel-resistant cells

S. Drapela, B. Kvokackova, R. Fedr, D. Kurfurstova, M. Morong, V. Student, W. M. van Weerden, M. Puhr, Z. Culig, J. Bouchal, K. Soucek

The paper identifies a 6-molecule surface fingerprint in primary prostate cancer tumors associated with docetaxel resistance, present before treatment.

bioRxiv · Jan 28, 2021Cancer Biology