A. P. Gomes

Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity

This study shows that methylmalonic acid impairs CD8+ T cell function and promotes tumor growth by inducing metabolic dysfunction and exhaustion.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

Interactions between ploidy and resource availability shape clonal interference at initiation and recurrence of glioblastoma

This study uses a mathematical model to show that ploidy and resource availability in the tumor microenvironment influence glioblastoma initiation and recurrence.

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

NADK upregulation is an essential metabolic adaptation that enables breast cancer metastatic colonization

This study identifies NADK upregulation as a critical metabolic adaptation enabling breast cancer metastasis by enhancing NADPH production and oxidative stress resistance.

CD5L constraints acute and systemic inflammation and can be a novel potent therapeutic agent against sepsis

This paper demonstrates that CD5L reduces sepsis severity by both anti-bacterial and anti-inflammatory mechanisms, showing therapeutic potential in mouse models.

Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.