Author

C. L. Mendias

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 7 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Organism:mouse· 7 Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Assay:proteomics· 4 Approach:statistical model· 4 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

N. P. Disser· 5 shared D. C. Sarver· 4 shared J. B. Swanson· 4 shared J. R. Talarek· 4 shared K. B. Sugg· 4 shared A. N. Piacentini· 2 shared B. McDonagh· 2 shared D. J. Oliver· 2 shared

Activity by Year

2017-2020 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersPhysiology

N. P. Disser

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Single-cell Transcriptomics Identify Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons

A. J. De Micheli, J. B. Swanson, N. P. Disser, L. M. Martinez, N. R. Walker, D. J. Oliver, B. D. Cosgrove, C. L. Mendias

The paper uses single-cell RNA sequencing to identify 11 cell types in mouse Achilles tendons, including three new fibroblast populations, and models cell interactions.

bioRxiv · Apr 2, 2020Cell Biology

Scleraxis is required for the growth of adult tendons in response to mechanical loading

J. P. Gumucio, M. M. Schonk, Y. A. Kharaz, E. Comerford, C. L. Mendias

This study shows that scleraxis is necessary for adult tendon growth in response to mechanical loading by promoting pericyte commitment to tenocytes and extracellular matrix production.

bioRxiv · Mar 18, 2020Cell Biology

Prostaglandin D2 Signaling is Not Involved in the Recovery of Rat Hindlimb Tendons from Injury

D. C. Sarver, K. B. Sugg, J. R. Talarek, J. B. Swanson, D. J. Oliver, A. C. Hinken, H. F. Kramer, C. L. Mendias

This study investigates the role of PGD2 signaling in tendon healing and finds that inhibiting HPGDS does not improve tendon recovery in rats.

bioRxiv · Nov 10, 2019 · PreprintPhysiology

Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy

D. W. Van Pelt, Y. A. Kharaz, D. C. Sarver, L. R. Eckhardt, J. T. Dzierzawski, N. P. Disser, A. N. Piacentini, E. Comerford, B. McDonagh, C. L. Mendias

The paper uses multiomics analysis to study dystrophic muscles in mdx/mTR mice, finding transcriptome and proteome changes related to protein balance and metabolism, with limited agreement between transcriptome and proteome fold changes.

bioRxiv · Oct 25, 2019Physiology

Adaptive and Innate Immune Cell Responses in Tendons and Lymph Nodes After Tendon Injury and Repair

A. C. Noah, T. M. Li, L. M. Martinez, S. Wada, J. B. Swanson, N. P. Disser, K. B. Sugg, S. A. Rodeo, T. T. Lu, C. L. Mendias

This study investigates adaptive and innate immune cell responses in tendons and lymph nodes after tendon injury, finding a coordinated adaptive immune response that may regulate healing.

bioRxiv · Oct 2, 2019Physiology

The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy And Weakness After Rotator Cuff Tear

J. R. Talarek, A. N. Piacentini, A. C. Konja, S. Wada, J. B. Swanson, S. C. Nussenzweig, J. S. Dines, S. A. Rodeo, C. L. Mendias

This study shows that MRL/MpJ mice, previously thought to be protected from muscle atrophy after rotator cuff tear, actually experience similar force loss and pathological changes as C57Bl/6 mice.

bioRxiv · Jul 14, 2019Physiology

Insulin-like growth factor 1 receptor signaling in tenocytes is required for adult tendon growth

N. P. Disser, K. B. Sugg, J. R. Talarek, D. C. Sarver, B. J. Rourke, C. L. Mendias

This study shows that IGF1 signaling in tenocytes is essential for postnatal tendon growth in response to mechanical loading.

bioRxiv · Jun 18, 2019Physiology

Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis

J. P. Gumucio, A. H. Qasawa, P. J. Ferrara, A. N. Malik, K. Funai, B. McDonagh, C. L. Mendias

This study identifies mitochondrial dysfunction and reduced fatty acid oxidation as causes of lipid accumulation in myosteatosis using a rat rotator cuff injury model.

bioRxiv · Nov 18, 2018Physiology

Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling

K. B. Sugg, J. F. Markworth, N. P. Disser, A. M. Rizzi, J. R. Talarek, D. C. Sarver, S. V. Brooks, C. L. Mendias

This study shows PDGFR signaling is essential for postnatal tendon growth and remodeling, with MT1-MMP mediating fibroblast migration and being regulated by PI3K/Akt and ERK1/2.

bioRxiv · Oct 25, 2017Physiology