Author

C. M. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

A. S. Herbert· 4 shared J. M. Dye· 4 shared D. Wrapp· 3 shared J. S. McLellan· 3 shared M. Sakharkar· 3 shared A. S. Wirchnianski· 2 shared A. Z. Wec· 2 shared C. Florez· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

A. S. Herbert

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Development and evaluation of a wearable peripheral vascular compensation sensor in a swine model of hemorrhage

F. Bonetta-Misteli, T. Collins, T. Pavek, M. Carlgren, A. Frolova, L. Shmuylovich, C. M. O'Brien

The paper develops and evaluates a wearable sensor to detect hemorrhage-induced peripheral vasoconstriction in swine, showing strong correlation with blood loss compared to shock index.

bioRxiv · Feb 20, 2023Bioengineering

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

D. Haslwanter, M. E. Dieterle, A. Z. Wec, C. M. O'Brien, M. Sakharkar, C. Florez, K. Tong, C. G. Rappazzo, G. Lasso, O. Vergnolle, A. S. Wirchnianski, R. H. Bortz, E. Laudermilch, J. M. Fels, A. Mengotto, , R. K. Jangra

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

mBio · Oct 26, 2021Peer-reviewedMicrobiology

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

C. G. Rappazzo, L. V. Tse, C. I. Kaku, D. Wrapp, M. Sakharkar, D. Huang, L. M. Deveau, T. J. Yockachonis, A. S. Herbert, M. B. Battles, C. M. O'Brien, M. E. Brown, J. C. Geoghegan, J. Belk, L. Peng, , L. M. Walker

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

bioRxiv · Nov 17, 2020 · PreprintImmunology

Animal Model Prescreening: Pre-exposure to SARS-CoV-2 impacts responses in the NHP model

K. M. Ricks, A. S. Herbert, J. W. Koehler, P. A. Kuehnert, T. L. Clements, C. J. Shoemaker, A. I. Kuehne, C. M. O'Brien, S. R. Coyne, K. L. Delp, K. S. Akers, J. M. Dye, J. W. Hooper, J. M. Smith, J. R. Kugelman, , T. D. Minogue

This study shows pre-exposure to SARS-CoV-2 affects biomarker responses in animal models, emphasizing the need for pre-screening protocols in medical countermeasure studies.

bioRxiv · Jul 6, 2020 · PreprintImmunology

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

A. Z. Wec, D. Wrapp, A. S. Herbert, D. P. Maurer, D. Haslwanter, M. Sakharkar, R. K. Jangra, M. E. Dieterle, A. Lilov, D. Huang, L. V. Tse, N. V. Johnson, C.-L. Hsieh, N. Wang, J. H. Nett, , L. M. Walker

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

bioRxiv · May 15, 2020 · PreprintImmunology