C. G. Rappazzo

Characteristics and functions of infection-enhancing antibodies to the N-terminal domain of SARS-CoV-2

This study identifies infection-enhancing antibodies targeting the N-terminal domain of SARS-CoV-2 spike protein, which persist in convalescent patients and may be counteracted by viral mutations.

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

Longitudinal single cell profiling of regulatory T cells identifies IL-33 as a driver of tumor immunosuppression

The paper identifies IL-33 as a driver of tumor immunosuppression by analyzing longitudinal single-cell RNA-Seq data of regulatory T cells in a mouse model of lung adenocarcinoma.