Author

C. R. Pfeifer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

D. E. Discher· 2 shared L. J. Dooling· 2 shared D. Liu· 1 shared E. G. Ricci-De Lucca· 1 shared E. J. Chen· 1 shared J. Irianto· 1 shared K. Pannell· 1 shared K. T. Simon· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

D. E. Discher

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2 papers

Recent·Most cited

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

C. R. Pfeifer, M. P. Tobin, S. Cho, M. Vashisth, L. J. Dooling, L. L. Vasquez, E. G. Ricci-De Lucca, K. T. Simon, D. E. Discher

The paper shows that high nuclear curvature causes lamin-B dilution and rupture, with lamin-A also contributing under high strain rates, suggesting a viscoplastic response to mechanical stress.

bioRxiv · Oct 13, 2021Biophysics

Rescue of DNA damage in cells after constricted migration reveals bimodal mechano-regulation of cell cycle

Y. Xia, C. R. Pfeifer, K. Zhu, J. Irianto, D. Liu, K. Pannell, E. J. Chen, L. J. Dooling, R. A. Greenberg, D. E. Discher

The paper investigates DNA damage and cell cycle effects during constricted cell migration, finding a bimodal relationship between DNA damage and cell cycle regulation.

bioRxiv · Dec 30, 2018Cell Biology